«Our results indicate that the
epigenetic modification we studied makes both mice and
humans more susceptible to obesity and with increasing
age increases their risk
of developing a fatty liver,» said Anne Kammel, first author
of the study.
Health improvement (allowing to post - pone / escape the diseases and thus live, healthier / disease - free longer, but not above
human MLSP
of around 122 years; thus these therapies do not affect
epigenetic aging whatsoever, they are degenerative
aging problems not regular healthy
aging problem (except OncoSENS - only when you Already Have Cancer - which cancer increases
epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal
epigenetic «
aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy
aging» all
aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms
of damage accumulating) that it does not affect their quality
of life (enough yet), that is «healthy
aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP)
of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow
humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their
age), and both are correlated to MLSP).
WIKIMEDIA, CSIROAfter
human somatic cells are reprogrammed into induced pluripotent stem cells (iPSCs), the resulting cells retain both genetic and
epigenetic indicators
of the
age of the person who donated the somatic - cell progenitors, scientists have found.
Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on
human health: Interreg CARDIOGENE (Genetic mechanisms
of cardiovascular diseases), GENCODYS (Genetic and
epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies
of brain
aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment
of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform
of signaling pathways involved in cancers.
Our model, which estimates
age based on DNA methylation at 329 unique CpG sites, has a median absolute error
of 3.33 weeks and has similar properties to the recently described
human epigenetic clock.