Sentences with phrase «epigenetic basis of»

This study shows that the coral reef fish has 193 genes correlated to such acclimation traits, suggesting an epigenetic basis of acclimation.

Following the award presentation, Feinberg will deliver a lecture on the epigenetic basis of common human disease.

Her research examines the epigenetic basis of complex brain functions and the heritability of acquired traits across generations in mammals.

Her scientific expertise lies in understanding the epigenetic basis of gene regulation during embryonic development and disease ontology.

Future studies of the genetic and epigenetic basis of disease development and progression may provide biomarkers and / or panels of biomarkers with improved specificity when compared to PSA.

«A change of heart: Epigenetic basis of cardiac hypertrophy uncovered.»

Not exact matches

Durect, Corp., a biopharmaceutical company developing therapeutics based on its epigenetic regulator program and proprietary drug delivery platforms, posted an all - time low of 61 cents in November 2012 before embarking on an uptrend that topped out at $ 3.42 in June 2015.

If, contrary to what I expect to be a genetic basis, the actual source of novelty is phenotypic plasticity or perhaps epigenetics, then I'll concede I was wrong.

She was the first person to identify the physiological mechanisms responsible for social monogamy, and her research interests focus on the neurobiological basis of behavior and the developmental and epigenetic effects of early experience.

DNA methylation — the addition of methyl groups to individual bases — is just one of many epigenetic markers of DNA and its associated proteins.

The Human Genome Project, which sequenced the 3 billion pairs of nucleotide bases in human DNA, was a piece of cake in comparison: Epigenetic markers and patterns are different in every tissue type in the human body and also change over time.

Based on the evolutionary idea that targeted epigenetic stochasticity can improve adaptation, these observations could explain how cancer cells are good at evading chemotherapy treatments and spreading from one part of the body to another, he adds.

A second, well - understood form of epigenetic signaling, called DNA methylation, involves the addition of a methyl group — a carbon atom plus three hydrogen atoms — to particular bases in the DNA sequence.

That question turned out to be the basis of a new field, behavioral epigenetics, now so vibrant it has spawned dozens of studies and suggested profound new treatments to heal the brain.

But to this base we must add some regulation, just like the spelling and grammar of that alphabet: this is what we call Epigenetics.

For example, their Boston - based innovation center launched with news of a $ 12.9 million deal to back Rodin Therapeutics, a Cambridge, Massachusetts - based biotech using epigenetics to develop novel therapeutics for neurological disorders, notably Alzheimer's disease.

«ChroGPS is based on the sequential application of two steps: first the generation of distances (or degrees of similarity) between epigenetic components on the basis of several possible measurements that we have developed, and after, in the representation of these distances in the form of bi - o tri-dimensional maps to facilitate their interpretation.For example, they are like visual maps from which distance tables can be drawn up in kilometers between cities,» describes Òscar Reina, one of the developers of the software application.

Those changes are epigenetic based; and then that leads to essentially permanent changes in maternal behavior in that pup once it grows up that then is passed onto the next generation through that offspring's licking of her pups.

The study of epigenetic changes in the body's hormone - based stress system has shown that stress - related changes in the CRH gene are linked to both serious suicide attempts in adults and psychiatric illness in adolescents.

Our side by side analysis uncovers the dynamics of epigenetic programming occurring in germ cell development at single base resolution in human and mouse cells.»

Today, an article published in Cell by Manel Esteller, director of the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute (IDIBELL), ICREA researcher and Professor of Genetics at the University of Barcelona, describes the possible existence of a sixth DNA base, the methyl - adenine (mA), which also help determine the epigenome and would therefore be key in the life of the cells.

The DKFZ researchers conducted this study in collaboration with Epiontis, a Berlin - based company that specializes in the epigenetic tests that were used to determine the ratio of the various T cell populations.

Unlike the rest of the genome, which is only inherited from an individual's parents (with random mutations here and there), methylation and other epigenetic annotations can be modified based on experience.

Professor Widschwendter says: «The data is encouraging since it shows the potential of a blood based epigenetic test to identify breast cancer risk in women without known predisposing genetic mutations.»

The TMWG kit incorporates Cambridge Epigenetix's TrueMethyl oxidative bisulfite (oxBS) technology, which allows researchers to accurately quantify different DNA modifications at single - base resolution, as well as proprietary library preparation methods designed to overcome the limitations of traditional bisulfite library construction, and to improve the yield and quality of epigenetic data.

In a review article published April 5 in the New England Journal of Medicine, scientist Andrew Feinberg, M.D., calls for more integration between two fields of DNA - based research: genetics and epigenetics.

One type of epigenetic change is methylation, where a methyl group is added to or removed from a base in the DNA molecule without affecting the original DNA sequence.

His research is based on the concept that normal brain aging and the pathogeneses of sporadic neurological diseases are not a consequence of a few single or «disease - specific «factors alone, rather they are driven by holistic events that include one's individual genetic and epigenetic condition, progression of aging, and lifestyle.

For the June issue of Men's Health, journalist Dan Crane wrote a story about this topic and discussed an epigenetics - based fertility test for men.

Marlinde L. van den Boogaard conduct analyses suggesting transcription of DUX4 in somatic cells is modified by variations in its epigenetic state and provide a basis for understanding the reduced penetrance of Facioscapulohumeral dystrophy (FSHD) within families.

However, researchers have been skeptical of blood - based epigenetic studies for one main reason: While the genome is the same in any cell from the same individual, the epigenome necessarily changes from tissue to tissue.

Participating institutions: Helmholtz Association • CNRS • Institute of Molecular Biotechnology • Research Center for Molecular Medicine of the Austrian Academy of Sciences • VIB - KU Leuven • Friedrich Miescher Institute for Biomedical Research • University of Basel • University of Zurich • Central European Institute of Technology • Max Planck Institute of Immunobiology and Epigenetics • Max Planck Institute for Molecular Genetics • German Cancer Research Center • Max Delbrück Center for Molecular Medicine • German Center for Neurodegenerative Diseases • Helmholtz Zentrum München • Max Planck Institute for Evolutionary Anthropology • Helmholtz Institute of RNA - based Infection Research • Saarland University • Technical University Munich • University of Würzburg • Biotech Research & Innovation Centre • Interdisciplinary Nanoscience Center • University of Copenhagen • Centre for Genomic Regulation • Institut Curie • Université de Montpellier • Inserm • Université Toulouse III — Paul Sabatier • École nationale supérieure des mines de Paris • Institute for Molecular Medicine Finland • The Biomedical Research Foundation, Academy of Athens • Weizmann Institute of Science • Hebrew University • Sapienza — University of Rome • Instituto Nazionale Genetica Molecolare • University of Napoli • University of Padua • University of Milan • European Institute of Oncology • Netherlands Cancer Institute • Radboud University • University Medical Center Utrecht • Hubrecht Institute • Instituto Gulbenkian de Ciência • Institute of Bioorganic Chemistry of the Polish Academy of Sciences • Romanian Center for Systems Immunology • Karolinska Institute • MRC Human Genetics Unit • University of Edinburgh • Wellcome Sanger Institute • The Babraham Institute • European Molecular Biology Laboratory — European Bioinformatics Institute

Below you'll find some of the CRISPR - based epigenetic modifiers avaliable from Addgene.

Our approach to unravelling epigenetic mechanisms and hierarchies is based on complementary uses of the yeast, S. cerevisiae and the mouse as experimental systems.

ONE - PARENT SAMPLE SET PARENTAL GUIDANCE RULES: Maternally methylated (red dots) and paternally methylated (blue dots) regions across the human autosomal chromosomes, based on studies of uniparental disomy samplesGENOME RES, 24:554 - 69, 2014 RESEARCHERS Kazuhiko Nakabayashi, Division Chief, Department of Maternal - Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan; David Monk, Principal Investigator, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research ORGANISM Human METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are expressed.

Using genetic and epigenetic analyses coupled with powerful perturbation technologies to test gene functions in human cells and mouse models, we hope to identify the critical drivers of this disease and the basis for therapeutic responses.

Determining how ES cell genes are modified by these epigenetic markers may explain these cells» unique characteristics, said the scientists, who are based at the Genome Institute of Singapore (GIS) and the Bioprocessing Technology Institute (BTI), both under the Agency for Science, Technology and Research (A * STAR), as well as at the National University of Singapore (NUS).

Objective: To understand, using a drosophila model, the molecular bases of the epigenetic transmission (i.e., independent of DNA sequences) of hereditary traits.

Methylation of cytosine bases is an epigenetic mechanism by which gene expression is regulated.

Topics covered include embryonic stem cells, pluripotency, germline stem cells, tissue - specific stem cells, stem cell differentiation, epigenetics, stem cell genomics and systems biology, genome reprogramming, cancer stem cells, stem cell niches, stem - cell - based disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging of stem cells, therapeutic applications, regenerative medicine, clinical and translational insights, stem cell research policies, ethical issues, and technical or resource - based innovations.

Molecular basis of scouting behaviors in honey bees Zhengzheng Liang, Neuroscience Program, University of Illinois at Urbana - Champaign, USA Dissociating epigenetic mechanisms of memory in the hippocampus and perirhinal cortex of rats Krista Mitchnick, Department of Psychology, Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada Determining the heritability of locomotor sensitization to ethanol and its relationship to ethanol's positive motivational effects in mice David Linsenbardt, Indiana Alcohol Research Center and Department of Psychology, Indiana University — Purdue University, Indianapolis, Indianapolis, Indiana, USA Rufy1 or Hnrnph1 is a likely quantitative trait gene for methamphetamine sensitivity Camron Bryant, Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics, Department of Psychiatry, Boston University School of Medicine, Massechusetts, USA

In January, TGI and its collaborators published three Nature papers that came online the same day: one on the genetic basis of an aggressive pediatric leukemia, another on genomic and epigenetic analyses of childhood retinoblastoma, and a third on tumor evolution in relapsed AML.

These data define a critical role for MORC2 in epigenetic silencing by the HUSH complex and provide a mechanistic basis underpinning the role of MORC2 mutations in CMT disease.

Our model, which estimates age based on DNA methylation at 329 unique CpG sites, has a median absolute error of 3.33 weeks and has similar properties to the recently described human epigenetic clock.

His work on aphids has broadened to examine the molecular basis of all aphid interactions with their environment, including the genetic and epigenetic factors controlling aphid polyphenism and the molecular basis of insecticide resistance.

The risk profile has a strong basis in epigenetics — the influence of diet and lifestyle on how particular genotypes are expressed.

The Primal Blueprint is based on lifestyle principles that have governed human health, evolution and peak performance for over two million years, and is supported by respected research in the fields of epigenetics and evolutionary biology.

«Many of the carcinogens present in mainstream smoke are known to exert their effects through a genotoxic mode of action, which is based on their ability to induce DNA damage and mutations, although an epigenetic mode of action, e.g., through aberrant DNA methylation and histone modifications, is also beginning to emerge for a few of these carcinogenic compounds.»

Consumers will be able to receive actionable recommendations of optimized skincare products to use, as well as assess the progress of their skincare routines, based on their skin's epigenetic profiles.

The neurobiological basis of human aggression: A review on genetic and epigenetic mechanisms.