«We already know that nutritional supplements for children can lead to lower ADHD and conduct problems, so it will be important for future research to examine the role of
epigenetic changes in this process.»
Not exact matches
The
epigenetic impairments reflect
changes that increase accessibility of chromatin, a
process that enhances gene transcription, suggesting the impairments play an important role
in addiction behavior.
«At this time, when prescription opioid use and opioid overdoses are both major threats to our public health, it is important to identify new treatment targets, such as
epigenetic processes, that help to
change the way that we do business
in treating opioid use disorders,» said professor John Krystal, Editor of Biological Psychiatry.
It is only now, more than three decades later, that science has the tools to see that this legacy of trauma becomes etched
in our DNA — a
process known as
epigenetics,
in which environmental factors trigger genetic
changes that may be passed on, just as surely as blue eyes and crooked smiles.
«The coolest thing from an environmental perspective is that we can ask whether diet can influence this
epigenetic process,» say Lanlan Shen of Baylor College of Medicine
in Houston, Texas, whose group has developed a way to direct where methylation occurs, allowing them to show that
epigenetic changes can trigger tumours (see main story).
The researchers linked the excess weight and
changes in metabolism to
epigenetic modifications that reduce expression of the gene for adiponectin — a hormone that helps regulate several metabolic
processes, including glucose regulation.
The black truffle uses reversible
epigenetic processes to regulate its genes, and adapt to
changes in its surroundings.
The way
epigenetics helps understand that
process is that it provides the mechanism by which maternal experience of a pup can essentially produce lifelong
changes in the brain because many
epigenetic changes are that stable.
The differences between male and female iPS cells are most pronounced for one of the key
processes in the field of
epigenetics: DNA methylation, a modification that
changes the activity of a DNA segment without
changing its sequence.
However, scientists have recently found that gene regulation can also happen
in an ongoing fashion through
epigenetic processes, with the potential to
change behavior throughout a lifetime.
Fernald's work suggests that
epigenetic processes may cause, rather than simply reflect,
changes in dominance status
in hierarchically organized species, said Tom Boyce, a professor at the University of California, San Francisco School of Medicine, who was not involved
in the study.
Major
epigenetic changes underlie the
process of
epigenetic reprogramming
in vivo and
in vitro (SCNT, iPS generation...).
RNAi and other
epigenetic processes induce
changes in where and when specific genes are expressed without altering their genetic code...
The
process, called
epigenetic change, can result
in her child tending to gain more fat.
«We're really trying to learn through molecular profiling analysis and a lot of
epigenetic changes how to beat cancer, but not beat the patient's brain
in the
process,» he says.
Advances
in neuroscience have revealed that the
process of brain development is driven by a dynamic interaction between the genome (nature) and the environment (nurture).25
Epigenetic mechanisms like DNA methylation and histone acetylation are able to transduce experiences with the environment into long - lasting, even intergenerational
changes in gene expression.26 — 35 So although the inherited genetic program is thought to provide a general blueprint for brain architecture, the environment is able to influence which genes are used, when they are used during the course of development, and where they are used within the developing brain.