Sentences with phrase «epigenetic changes occur»

Some studies have identified a number of regions of methylated DNA (one key way in which epigenetic changes occur) that are different in fat cells of mice fed high - fat diets than in cells of mice with normal diets.

The claim follows that life experiences are so devastating for the individual (or group of people) that epigenetic changes occur and are passed on to the next generation and to the next and so on.

Similarly, other epigenetic changes occur in how DNA and proteins are compacted in the nucleus of the cell.

An interesting and potentially very important novel finding was that a majority of the epigenetic changes occurred in regulatory regions of our genome, so called enhancers.

In agreement with the hypothesis that such adaptations are due to epigenetic changes occurring during preimplantation, we have detected epigenetic labile genes in the mouse embryo genomes that allow us to study the best IVC method to produce competent and healthy embryos to ensure that assisted reproductive technologies are utilized in the most efficient and safest possible manner.

Not exact matches

Baylin and Johns Hopkins scientist Michelle Vaz, Ph.D., first author on the study, suspected that the interplay of epigenetic and genetic changes may occur when normal lung cells develop into cancer, but, Baylin says, the timing of such changes was unknown.

In other words, the greater the amount of epigenetic change — and the more quickly it occurred — the shorter the species» lifespan.

The two - step process of TILT — getting sick upon toxicant exposure and failing to get well — may be driven by epigenetic changes, which occur when the environment alters the expression of genes without changing the core DNA code itself.

In a new study published in the Journal of Allergy and Clinical Immunology, researchers have now found a new principle for how epigenetic changes can occur.

In a new study, researchers at Uppsala University have found evidence of a new principle for how epigenetic changes can occur.

«The coolest thing from an environmental perspective is that we can ask whether diet can influence this epigenetic process,» say Lanlan Shen of Baylor College of Medicine in Houston, Texas, whose group has developed a way to direct where methylation occurs, allowing them to show that epigenetic changes can trigger tumours (see main story).

And because epigenetic changes typically occur early in life, it may one day be possible to identify young people at risk for suicide by studying their methylation patterns and then to treat them with drugs that regulate this mechanism, Szyf notes.

The brain attempts to adapt and respond to those challenges and that occurs in large part through changes in expression of brain genes through epigenetic mechanisms.

One type of epigenetic change to the genome occurs when small chemical groups glom on to the ladder structure of DNA.

But because the vinclozolin - induced fertility changes occurred in almost every male rat descended from a treated mother rather than in a small percentage of offspring (as is seen in germ line mutations caused by radiation), Skinner suspects an epigenetic mechanism — a change that doesn't mutate the DNA sequence of an animal, but rather affects how genes are expressed.

«Our interpretation of these results is that epigenetic changes that occur already in inflamed pancreatic tissue lead to reduced production of miR - 192.

It is therefore likely that it also occurs epigenetic changes associated a heart attack», says Åsa Johansson, a researcher at the Department of Immunology, Genetics and Pathology, who led the study.

As we improve methods to identify epigenetic changes that occur during tumor development, can we develop approaches to discriminate between «driver» and «passenger» epigenetic events?

The aims of the CEMC are to define the step-wise molecular and cellular alterations that occur during the process of carcinogenesis; determine how environmental exposures cause key genetic mutations and epigenetic changes that underlie carcinogenesis; and discover the impact of environmental factors on the generation and maintenance of cancer stem cells.

Epigenetic changes likewise occur during the creation of iPSCs, but it was unknown how reprogramming affected age - related epigeneEpigenetic changes likewise occur during the creation of iPSCs, but it was unknown how reprogramming affected age - related epigeneticepigenetic marks.

Scientists first coined the term «epigenetic» (which literally means «above the genome») in the 1940s as a way of classifying changes that occurred between genome and phenotype.

The afternoon of the second day focused on somatic changes in melanoma, that is changes that occur in the tumour itself, and this session saw talks from ESR07 Sofia Chen on the mutational landscape of primary melanoma tumours; ESR08 Catarina Salgado on DNA hydroxymethylation (a form of regulation) in melanoma and naevi; and ESR10 Adriana Sanna on epigenetic regulation (reversible changes to the DNA which can turn genes on / off) of melanoma cell phenotypes.

Some of the epigenetic variation that occurs between identical twins is likely because of random changes, says Nessa Carey.

In the present study, we test this hypothesis by examining epigenetic and transcriptional changes associated with naturally occurring differences in maternal care.