Epigenetic data spanning a much longer interval in human prehistory could reveal that the process was key to adapting quickly to a wide range of environmental conditions during the Pleistocene.
«Cross-tissue integration of genetic and
epigenetic data offers insight into autism spectrum disorder» was written by Shan V. Andrews, Shannon E. Ellis, Kelly M. Bakulski, Brooke Sheppard, Lisa A. Croen, Irva Hertz - Picciotto, Craig J. Newschaffer, Andrew P. Feinberg, Dan E. Arking, Christine Ladd - Acosta, M. Daniele Fallin
And although brain tissue — the tissue most affected by ASD — might yield the most
useful epigenetic data, it can't be sampled from living individuals.
The TMWG kit incorporates Cambridge Epigenetix's TrueMethyl oxidative bisulfite (oxBS) technology, which allows researchers to accurately quantify different DNA modifications at single - base resolution, as well as proprietary library preparation methods designed to overcome the limitations of traditional bisulfite library construction, and to improve the yield and quality
of epigenetic data.
Integrated with
the epigenetic data, these haplotypes revealed that: