Sentences with phrase «epigenetic effects on»

Paternal depression is also known to affect sperm quality, have epigenetic effects on the DNA of the baby, and can also affect placenta function.

Tattersall explains how epigenetic effects on key genes cascade to produce radical morphological changes in an eye blink, and why our unusual thinking style, far from being the perfected product of long - term selective pressures, was bootstrapped out of existing abilities barely 100,000 years ago.

The evidence for epigenetic effects on emotion regulation is quite solid: Early caregiving experiences can affect the expression of the genes that regulate a baby's stress and they can shape how the endocrine system will mobilize to stress.

Not exact matches

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

They are epigenetic: the result of generations of toxins, and the effect of these toxins on our genetics.

She was the first person to identify the physiological mechanisms responsible for social monogamy, and her research interests focus on the neurobiological basis of behavior and the developmental and epigenetic effects of early experience.

I would like to see studies that focussed on African Americans who are multigenerational «Jack and Jill» members, although that would perhaps not completely override potential epigenetic effects of hundreds of years of slavery and Jim Crow.

Subsequent research undertaken at the University of Glasgow has indicated that such health inequalities may be due, at least in part, to epigenetic effects resulting from socio - economic circumstances - http://medicalxpress.com/news/2012-01-health-inequalities-imprinted-dna.html The Economic and Social Research Council (ESRC) is the UK's largest organisation for funding research on economic and social issues.

Fang and her colleagues have since gone on to show that genistein and other compounds in soy show similar epigenetic effects.

With epigenetics we mean such changes in genes that are not determined by changes in the actual DNA sequence, but effects that are superimposed on this, caused for example by environmental effects.

The principle is based on an enzyme, tryptase, that has epigenetic effects that cause cells to proliferate in an uncontrolled manner.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

Shen is now researching whether diet has any effect on the epigenetic changes in mice with cancer.

Another study by a different group in the same journal in October 2009 looked at ART effects on epigenetics (non-DNA changes in genes) in humans.

Such transient effects of environmental factors to which earlier generations were exposed on the expression of characteristics in their progeny illustrate the unique, pliable nature of this epigenetic mechanism.

The drug had no effect on the epigenetic state of DNA taken from the local metastasis but reversed the epigenetic changes seen in cells from the distant metastasis.

Early results from a larger, ongoing study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst suggest that phthalate levels in expectant fathers have an effect on couples» reproductive success via epigenetic modifications of sperm DNA.

Fusco's group also showed that the effects on memory continued on to the next generation of mice, possibly due to epigenetic effects, chemical changes that turn genes off or on.

However, the downstream effects of these epigenetic changes on child development and health aren't known yet.

Epigenetic changes at key points in the pathway through which testosterone exerts its effects on the fetus could blunt or enhance the hormone's activity as needed, the authors suggest.

«Effect of environmental epigenetics on disease, evolution: «Epigenetics can drive genetics,» experts epigenetics on disease, evolution: «Epigenetics can drive genetics,» experts Epigenetics can drive genetics,» experts say.»

Washington State University researchers say environmental factors are having an underappreciated effect on the course of disease and evolution by prompting genetic mutations through epigenetics, a process by which genes are turned on and off independent of an organism's DNA sequence.

In this webinar, viewers will gain insight into the current status of epigenetics research, with an emphasis on understanding the mechanism and effects of DNA methylation.

AMHERST, Mass. — A new three - year, $ 440,000 study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst is now underway to investigate whether phthalate levels in expectant fathers have an effect on the couples» reproductive success, via epigenetic modifications of sperm DNA.

PULLMAN, Wash. — Washington State University researchers say environmental factors are having an underappreciated effect on the course of disease and evolution by prompting genetic mutations through epigenetics, a process by which genes are turned on and off independent of an organism's DNA sequence.

Research Project Grant (R01) applications proposing to conduct mechanistic studies in humans and animal models on alcohol - induced transgenerational effects and the role of epigenetic inheritance in these effects.

His group is are studying the mechanism of stable inherited epigenetic transcriptional repression by Polycomb - group (Pc - G) protein complexes, and the effects of deregulation of Pc - G genes on Homeobox gene expression, development, Cell cycle control and cancer formation.

Molecular basis of scouting behaviors in honey bees Zhengzheng Liang, Neuroscience Program, University of Illinois at Urbana - Champaign, USA Dissociating epigenetic mechanisms of memory in the hippocampus and perirhinal cortex of rats Krista Mitchnick, Department of Psychology, Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada Determining the heritability of locomotor sensitization to ethanol and its relationship to ethanol's positive motivational effects in mice David Linsenbardt, Indiana Alcohol Research Center and Department of Psychology, Indiana University — Purdue University, Indianapolis, Indianapolis, Indiana, USA Rufy1 or Hnrnph1 is a likely quantitative trait gene for methamphetamine sensitivity Camron Bryant, Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics, Department of Psychiatry, Boston University School of Medicine, Massechusetts, USA

The researchers are now looking at whether epigenetic effects no longer have an impact on great - grandchildren and their subsequent offspring.

The best understood epigenetic effects are caused by a mechanism known as «methylation» in which the molecule methyl attaches itself to our DNA and acts to switch genes on or off.

«Study of the pro-apoptotic effect of molecules interfering with epigenetic mechanisms on human lung cancer cells».

It has been demonstrated that the composition of the medium used for embryo culture has a profound effect on the methylation pattern in the resultant two - cell embryos [10], indicating that, in addition to imprinted genes, other epigenetic alterations may intensely modify gene expression.

In addition to effects on translation and DNA replication gene expression, high - replicate RNA - seq in morphologically normal individuals demonstrates a stable regulatory response of epigenetic modifiers and the specific de-repression of a group of zinc finger genes residing in constitutive heterochromatin.

«EPIGENETIC THERAPY OF LUNG CANCERS: Anti-tumoral effect of valproate on small cell lung cancer».

Tinkering with gene switches can have a profound effect on how they behave, and labs around the world are now scanning the genome in hopes of identifying epigenetic modifications — sometimes called «marks» or «tags» — that could serve as biomarkers, helping to predict and identify a wide range of conditions.

Previously, Dr. Ray completed her PhD at Harvard University with Dr. Robert Kingston, studying the effects of long non-coding RNAs on epigenetic regulation.

Finally, we analyzed, through gene silencing, the effect of IVC on the mRNA expression at the blastocyst stage for 11 known gene expression modifiers of epigenetic reprogramming.

It will also enhance our understanding of the epigenetic mechanisms by which choline may exert its effects on human health.

The workshop will focus on topics such as; hematopoietic stem cell biology, leukemogenesis, cell signaling, transcription factors, epigenetic effects, and other topics related to myeloid biology.

The understanding of «Food as Medicine» has always had its passionate advocates, and with the emergence of Epigenetics, cutting edge science is helping to explain the cellular effects food has on our bodies.

The media is riveted by Angelina Jolie's double mastectomy to address her doctor's prediction that she had an 87 % risk of breast cancer due to defects in her BRCA1 and / or BRCA2 genes, yet I've seen no mention of epigenetics and its effects on cancer development in relation to this story, thus no mention of the power of diet or lifestyle in cutting one's breast cancer risk.

We've known for quite a while that stress in the dam during pregnancy can have an effect on the pups» anxiety levels and general resiliency due to the high levels of stress hormones the babies are exposed to in utero, but the research on epigenetics is adding a whole new layer to consider.

«Many of the carcinogens present in mainstream smoke are known to exert their effects through a genotoxic mode of action, which is based on their ability to induce DNA damage and mutations, although an epigenetic mode of action, e.g., through aberrant DNA methylation and histone modifications, is also beginning to emerge for a few of these carcinogenic compounds.»

The current results suggest that protective parenting measured during late childhood and early adolescence may also exert an influence on genomic functioning and health in young adults, and contributes to promising work on multiple fronts suggesting that various epigenetic mechanisms may be related to, and help account for, long - term effects of protective parenting on health.

Stress paradigms in rodent models have been associated with elevated anxiety and contrasting alterations in neuronal morphology in the hippocampus and amygdala, with dendritic atrophy observed in the hippocampus and increased dendritic arborization in the amygdala.12, 13 Developing rodents deprived of maternal nurturance show decreased hippocampal volume and altered stress reactivity.14 An epigenetic mechanism for this effect has been elaborated.15 Importantly, controlled trials that have randomized institutionalized toddlers to early therapeutic foster care vs institutionalization have documented the deleterious effects of early relative deprivation on cognitive outcomes.16

Maternal care is associated with long - term effects on behavior and epigenetic programming of the NR3C1 (GLUCOCORTICOID RECEPTOR) gene in the hippocampus of both rats and humans.

His research includes investigating the effects of community - level factors, maternal psychosocial factors (e.g., trauma), and offspring epigenetic influences on early childhood development; the evaluation of approaches to improve service engagement; and the use of quasi-experimental methods and large administrative datasets to estimate the causal effects of home visiting on maternal and child health outcomes.

Results indicated that intervention effects on reductions in harsh parenting accounted for the association between parental depression levels and slower epigenetic aging among offspring.

Al (2011) Suggest many aspects of urban living — ranging from life stressors to the use of drugs, can have an effect on human epigenetics.