In particular, I will focus on the role for the antagonism between various transcription factors and
epigenetic enzymes in controlling the commitment of muscle stem cells towards alternate cell fates.
By identifying the epigenetic determinants and the responsible
epigenetic enzymes controlling these different forms of cardiac myocyte hypertrophy, as well as how the epigenetic modifiers are themselves regulated by micoRNAs, we provide a potential strategy for epigenetic therapy for adverse cardiac remodelling.
The researchers next used a cutting - edge technique that
encourages epigenetic enzymes to bind to DNA, allowing them to identify all the genes inhibited by HDAC5.
While various molecular biology techniques were initially used to identify and
validate epigenetics enzymes and their substrates, novel approaches are now available to perform pharmacological characterization of histone - modifying enzymes.
However, despite great strides in identifying the
various epigenetic enzymes / factors involved in cancer, the translational application of these findings in cancer intervention remains to be explored.
In this presentation, our studies on the role of transcription factors and
epigenetic enzymes in dictating changes in muscle gene expression will be highlighted.
Cowan and his fellow researchers had previously found that
the epigenetic enzyme histone deacetylase 5 (HDAC5) slows the rodent brain from forming associations between cocaine and simple cues in the environment, such as light and sound.
Epigenetic enzymes are now among the most important pharmaceutical targets due to their involvement in numerous key cellular processes and in the etiology of many devastating diseases including cancer, neurodegenerative disease, and developmental disorders.
A team with the Freiburg researchers Prof. Dr. Roland Schuele and Dr. Delphine Duteil has now shown that
the epigenetic enzyme lysine - specific demethylase 1 (Lsd1) plays a key role in maintaining the metabolic properties of brown fat.
Researchers have now shown that
an epigenetic enzyme called lysine specific demethylase 1 (Lsd1) plays a major part in this transformation.