Sentences with phrase «epigenetic enzymes in»

Not exact matches

Cowan and his fellow researchers had previously found that the epigenetic enzyme histone deacetylase 5 (HDAC5) slows the rodent brain from forming associations between cocaine and simple cues in the environment, such as light and sound.

The principle is based on an enzyme, tryptase, that has epigenetic effects that cause cells to proliferate in an uncontrolled manner.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.

All animals use the same enzyme to create the same methylation mark as a signal for gene repression, and her colleagues who study epigenetics in mice and humans are excited about the new findings, Strome said.

Already, Surani's and Hanna's groups have used the artificial PGCs to investigate the role of individual enzymes in epigenetic regulation, which may one day show how the epigenetic networks are involved in disease.

Before now, a lot of this epigenetic research had been done in yeast — single cell organisms that also use enzymes to lay chemical tags on histone proteins.

The team has been able to prove that such epigenetic alterations are associated with the increased levels of an enzyme, namely DNA methyltransferase 3A (DNMT3A), which is responsible for the acquisition of the suppressive properties of these cells that develop in the tumoral microenvironment.

This study represents a step forward in understanding the underlying mechanisms of T - cell function and epigenetic regulation of the HDAC11 enzyme.

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion.

My research centralized around the role of epigenetic enzymes — KDM5s and EZH2 in multiple cancers.

We are exploring the roles for epigenetic enzymes, small non-coding RNAs, and DICER 1 in the initiation and maintenance of abnormal DNA methylation patterns in cancer.

Researchers have now shown that an epigenetic enzyme called lysine specific demethylase 1 (Lsd1) plays a major part in this transformation.