Sentences with phrase «epigenetic events»

The next steps are to capture what happens in the later stages of primordial germ cell development and the related epigenetic events.

«It is expected that this study will lay the foundation for developing a new class of potent and effective cancer therapies and the development of reagents targeting epigenetic events in immune - mediated diseases as well as other epigenetically - influenced diseases,» said Alani, who also is chief of dermatology at Boston Medical Center.

So, thanks to a Catalan government ICREA (Catalan Institution of Research and Advanced Studies) award, designed to lure senior scientists working abroad to the region, this up - and - coming Italian researcher will shortly move to CRG to lead a group studying epigenetic events in cancer.

Researchers of the Chromatin and Disease Group from the Bellvitge Biomedical Research Institute (IDIBELL) in Barcelona have identified a distinctive epigenetic event in immune cells that differentiate in the tumoral microenvironment and make them tolerant to cancer cells.

As we improve methods to identify epigenetic changes that occur during tumor development, can we develop approaches to discriminate between «driver» and «passenger» epigenetic events?

For instance, oncogenic activation of the WNT / beta - catenin signaling cascade, which often comprises cooperating genetic and / or epigenetic events, is the most common tumour - initiating hallmark in neoplastic intestinal stem cells for sporadic colorectal cancer.

To evaluate histone modification (another epigenetic event), the authors employed chromatin immunoprecipitation with high - throughput sequencing (CHiP - Seq) to capture DNA sequences bound by H3 histones marking active (K4me1, K4me3, K27ac, K36me3) or repressed (K27me3, K9me3) chromatin.

The research provides further evidence that genetic and epigenetic events are both important in establishing different subgroups of ALL.

Dr. Volanakis is interested in the genetic and epigenetic events that contribute to the pathogenesis and progression of acute leukemia.