Sentences with phrase «epigenetic landscape»

In a companion study also published in Science, Nick Haining, MD, and colleagues from Dana - Farber Cancer Institute, also found a distinct epigenetic landscape for exhausted T cells in mice and humans, and they were able to ascribe key functions in T cell exhaustion to some of these epigenetic changes.

«We also found that this variant, H3.3, is modified by methylation to create a specific epigenetic landscape that is accommodated by the tumor - suppressing protein ZMYND11.

Targeting ecRNAs in the brain could be an attractive therapeutic approach to reorganizing epigenetic landscapes at specific genes, thus alleviating longstanding pathologies associated with dysfunctional methylation patterns.

The stabilized pathway of change is named a «chreod,» and the whole system of chreods in a complex developing system such as an egg gives rise to an «epigenetic landscape.»

She has dedicated her career to helping others understand the science of happiness and its powerful effects on everyday human health by harnessing the power of the epigenetic landscape.

«This is the first conclusive demonstration that the disease develops as a result of alterations in the epigenetic landscape and not from classical genetic mutations.»

The variation in the epigenetic landscapes of the three cell types was staggering.

Together, our findings suggest a shared mechanism of action for the gateway drugs alcohol and nicotine, and reveal a novel mechanism by which environmental factors may alter the epigenetic landscape of the reward system to increase vulnerability to cocaine addiction.

«With a better understanding of the epigenetic landscapes in cancers, we are going to have more tools to study the basis of tumorigenesis,» says Ren.

The ability to map «epigenomes» using such a small number of cells will be valuable to cancer research, since the epigenetic landscape is dramatically rearranged in cancer and contributes to phenomena driven by small subpopulations of cells, such as drug resistance and metastasis.

In the certain way you can imagine, or look at it like if you recall the epigenetic landscape of wanting that the valley gets deeper and deeper, and it gets more and more complicated to overcome the hill that then is building up and prevents to change the cell identity.

One of the main objectives is to investigate genome - wide changes in the epigenetic landscape of leukemic cells.

Regulation of the epigenetic landscape by the formation and resolution of RNA - containing chromatin structures

RNA - directed DNA methylation links the epigenetic landscape to the ecological adaptations manifested in the morphology of the toe pads.

Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass

Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common autoimmune disease that affects more than 1.3 million Americans.

We want to understand this observation through the investigation of gene regulation in the context of the epigenetic landscape.