Sentences with phrase «epigenetic marks characterizing»
A major finding of this study is that the genetic loci associated with asthma are enriched in epigenetic marks characterizing gene enhancers.
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«We note that there are two subgroups of breast tumors by epigenome: one which we have called Epi - Basal, characterized by loss of epigenetic marks causing breakage of chromosomes and the other that we have called Epi - Luminal B, that presents epigenetic inactivation of genes that should protect us from cancer and these altered cells can no longer do it.»
The overall goal of the core is to provide support to investigators interested in characterizing the interactions of post-translational modifications of histones (epigenetic marks that define a chromatin state or Epigenome) or transcription factors at specific genomic loci or genome - wide (Cistrome).
The pluripotent population is characterized by a high degree of plasticity in chromatin structure [3], and lineage specific transcription factors show bivalent chromatin epigenetic marks characteristic of both suppression and inactivation [4].