Sentences with phrase «epigenetic mechanism for»

Stress paradigms in rodent models have been associated with elevated anxiety and contrasting alterations in neuronal morphology in the hippocampus and amygdala, with dendritic atrophy observed in the hippocampus and increased dendritic arborization in the amygdala.12, 13 Developing rodents deprived of maternal nurturance show decreased hippocampal volume and altered stress reactivity.14 An epigenetic mechanism for this effect has been elaborated.15 Importantly, controlled trials that have randomized institutionalized toddlers to early therapeutic foster care vs institutionalization have documented the deleterious effects of early relative deprivation on cognitive outcomes.16

Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes, including those for cell cycle regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).

It is an epigenetic mechanism for the passage of information from the maternal oocyte to the zygote.»

«We've found that the brain uses these epigenetic mechanisms for its own purposes and in its own fashion.

Not exact matches

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

She was the first person to identify the physiological mechanisms responsible for social monogamy, and her research interests focus on the neurobiological basis of behavior and the developmental and epigenetic effects of early experience.

With increased understanding of the fundamental mechanism, appropriate DNA methylation including the proper functioning of the epigenetic machinery is highlighted to be essential for embryogenesis and adult health [1]- [3].

For 50 years, the fundamental principles and mechanisms of the epigenetic regulation of gene expression have been explored across myriad organisms and human diseases.

The reasons for these changes are unclear, although environmental and epigenetic mechanisms (where environmental factors affect genetics) are likely to be involved.

For example, genes involved in suppressing tumor formation are turned off via epigenetic mechanisms, and genes involved in rapid growth and replication are turned on too high.

And because epigenetic changes typically occur early in life, it may one day be possible to identify young people at risk for suicide by studying their methylation patterns and then to treat them with drugs that regulate this mechanism, Szyf notes.

Instead, AP2 - G can be activated by epigenetic mechanisms providing a plausible explanation for how low - level sexual conversion is triggered,» says Cortés.

Further, since the disruption of epigenetic mechanisms may cause diseases such as cancer, diabetes and autoimmune disorders, these new findings could have implications for human health.

«Future studies on maternal smoking and other environmental, genetic, and epigenetic factors, as well as animal models, should allow identification of the biological mechanisms responsible for these associations.

To understand the underlying mechanism for how this may occur, she is also conducting epigenetic studies to determine where in the genome this acclimatization effect takes place.

Finally, a profound understanding of the molecular mechanisms underlying reprogramming, and knowledge of the epigenetic barriers that interfere or block lineage conversion, will allow for developing even better reprogramming strategies; and, thus, also feed the aim of obtaining authentic neurons.

«Our findings suggest that molecular mechanisms for epigenetic regulation within the spinal cord constitute the starting point for handedness,» said Ocklenburg from Ruhr University Bochum in Germany.

Such epigenetic mechanisms have already been exploited for diagnosis and treatment; for example, DNA hypomethylation therapy with 5 - azacytidine is approved for MDS and is in clinical trials for some other cancers.

The first of its kind, the study provided specific markers to distinguish different disease states in asthma and paved the way for investigating the role of epigenetic mechanisms in other immune - mediated disorders and infectious diseases.

Molecular basis of scouting behaviors in honey bees Zhengzheng Liang, Neuroscience Program, University of Illinois at Urbana - Champaign, USA Dissociating epigenetic mechanisms of memory in the hippocampus and perirhinal cortex of rats Krista Mitchnick, Department of Psychology, Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada Determining the heritability of locomotor sensitization to ethanol and its relationship to ethanol's positive motivational effects in mice David Linsenbardt, Indiana Alcohol Research Center and Department of Psychology, Indiana University — Purdue University, Indianapolis, Indianapolis, Indiana, USA Rufy1 or Hnrnph1 is a likely quantitative trait gene for methamphetamine sensitivity Camron Bryant, Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics, Department of Psychiatry, Boston University School of Medicine, Massechusetts, USA

Increased understanding of epigenetic disease mechanisms, including natural and anthropogenic environment factors, could lead to disease risk stratification for targeted intervention and to targeted therapies.

Increased understanding of epigenetic disease mechanisms could lead to disease risk stratification for targeted intervention and to targeted therapies [6].

Landmark research published by City of Hope researchers showed, for the first time, a connection between complex epigenetic mechanisms, blood glucose levels and diabetic complications in patients with metabolic memory.

Understanding epigenetic mechanisms and their contribution to the persistence of diabetic complications is critical because it could suggest alternative targets for therapy to halt and reverse complications.

For Paro, epigenetic mechanisms form an additional, paramount level of information to the genetic information of DNA.

«If we can reprogram this epigenetic mechanism, then the therapy might work for more patients,» says Zou, Charles B. de Nancrede Professor of Surgery, Immunology and Biology at the University of Michigan Medical School.

Research on epigenetics, including its mechanisms and drivers, will elucidate highly valuable targets and lead to potentially transformative treatment regimens for hematologic disorders.

The current results suggest that protective parenting measured during late childhood and early adolescence may also exert an influence on genomic functioning and health in young adults, and contributes to promising work on multiple fronts suggesting that various epigenetic mechanisms may be related to, and help account for, long - term effects of protective parenting on health.

Several candidate mechanisms of CRCI have been proposed, including inflammation and cytokine dysregulation, chemotherapy - induced epigenetic changes, blood — brain barrier disruption, hormone deficiencies, oxidative DNA damage and shortened telomere length, and genetic susceptibility.21 — 26 However, the heterogeneity and design limitations within the emerging body of evidence have led to recommendations for harmonising study methodologies and moving towards multisite, longitudinal research.3 27 Such approaches would support the demonstration of robust relationships between measurable biological processes and cognitive outcomes.

Advances in neuroscience have revealed that the process of brain development is driven by a dynamic interaction between the genome (nature) and the environment (nurture).25 Epigenetic mechanisms like DNA methylation and histone acetylation are able to transduce experiences with the environment into long - lasting, even intergenerational changes in gene expression.26 — 35 So although the inherited genetic program is thought to provide a general blueprint for brain architecture, the environment is able to influence which genes are used, when they are used during the course of development, and where they are used within the developing brain.

Initial research results indicate a functional role for epigenetic mechanisms in neuron development and neuronal cell function.