Sentences with phrase «epigenetic mechanisms as»

Based on a modified version of Gottlieb's scheme of psychobiological development, this study conceptualizes epigenetic mechanisms as molecular underpinnings mediating interactions between neural and... genetic activity levels.

Based on a modified version of Gottlieb's scheme of psychobiological development, this study conceptualizes epigenetic mechanisms as molecular underpinnings mediating interactions between neural and

Not exact matches

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

Many suspect these changes can pass on to offspring through sperm and eggs, a mechanism known as epigenetic inheritance.

Such epigenetic mechanisms are high on the list of suspects when it comes to explaining how environmental factors that affect parents can later influence their children, such as in the Dutch second world war study, but just how these epigenetic changes might be passed on to future generations is a mystery.

But as you said, as an individual eats a high - fat diet or is exposed to other types of environmental exposures, the ability of the liver to adapt involves turning on and turning off certain liver genes to control the liver's activity, and that's mediated through these epigenetic mechanisms that modify the activity of established liver genes.

And we now know that it is the same epigenetic mechanisms that occur in brain as occur in liver, just involving, only the specifics differ — brain genes in brain, liver genes in liver.

He notes that because of the boggling number of potential factors, such as copy number variations, point mutations and epigenetic (inherited mutation) factors involved in autism, it will be important to find common pathways «because the mechanisms interrupting those pathways might be different among individuals.»

Further, since the disruption of epigenetic mechanisms may cause diseases such as cancer, diabetes and autoimmune disorders, these new findings could have implications for human health.

And it was in the late 90's when mC was recognized as the main cause of epigenetic mechanisms: it is able to switch genes on or off depending on the physiological needs of each tissue.

By studying this new mechanism we hope to expand our knowledge of epigenetics in general as well as adding to our understanding of fertility.»

«Future studies on maternal smoking and other environmental, genetic, and epigenetic factors, as well as animal models, should allow identification of the biological mechanisms responsible for these associations.

Many researchers believe that these changes can be passed down through sperm and eggs — a mechanism known as epigenetic inheritance.

Epigenetics is being recognized as an increasingly important area of research that involves an understanding of the molecular mechanisms that influence the phenotypic outcome of the genome without alteration of the DNA sequence.

But because the vinclozolin - induced fertility changes occurred in almost every male rat descended from a treated mother rather than in a small percentage of offspring (as is seen in germ line mutations caused by radiation), Skinner suspects an epigenetic mechanism — a change that doesn't mutate the DNA sequence of an animal, but rather affects how genes are expressed.

The methylation of DNA is one of the epigenetic mechanisms regulating the functioning of the genome, influenced by not only by variations in DNA sequence, but also environmental factors such as fluctuations in the circadian rhythm.

FOXA1 activation, inducing enhancer reprogramming that endows a cancer cell with metastatic properties, is an epigenetic mechanism, as opposed to a genetic one, that explains at least one mechanism of metastasis in this form of pancreatic cancer, and likely, other cancer types as well.

Our approach to unravelling epigenetic mechanisms and hierarchies is based on complementary uses of the yeast, S. cerevisiae and the mouse as experimental systems.

«This discovery will advance our understanding of stem cell epigenetics and chromatin structures, provide potential mechanisms on maintaining the hallmark properties of ES cells, and help researchers with the rich source of information to better understand some of the unique features — such as self - renewal and pluripotency — of human embryonic stem cells,» said Ng Huck Hui, Ph.D., senior group leader at GIS and a member of the Singapore team that conducted this research.

Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies of brain aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform of signaling pathways involved in cancers.

Research Focus: I dedicate my time and effort to develop high - throughput sequencing technologies such as single cell transcriptomic, ChIP - Seq, ChIA - PET, and many more... The scientific rational is to understand better and with a different angle, the mechanisms of epigenetic regulation of gene expression in (rare) immune cells, pathologically relevant in many diseases such as asthma, SLE, tuberculosis...

In contrast, many scientists consider that chromatin does not form an independent epigenetic layer of the genome and that chromatin modifiers do not operate independently of a DNA sequence specific targeting mechanism, such as transcription factors.

The best understood epigenetic effects are caused by a mechanism known as «methylation» in which the molecule methyl attaches itself to our DNA and acts to switch genes on or off.

In his view, new characteristics are generated and passed on via epigenetics, subject to the same mechanisms of evolution as those with a purely genetic origin.

Changes in an epigenetic mechanism that turns expression of genes on and off may be as important as genetic alterations in causing pediatric acute lymphoblastic leukemia (ALL), according to a study led by scientists at St. Jude Children's Research Hospital and published in the June 10 online edition of the Journal of Clinical Investigation.

2Research has proven these curcuminoids exert powerful health - promoting effects via 160 mechanisms and pathways in the body such as antioxidant, neuroprotective, immunomodulatory, anti-inflammatory, epigenetic, and adaptogenic properties.