Sentences with phrase «epigenetic modification regulates»
A messenger RNA epigenetic modification regulates stem cell progression from the pluripotent to the differentiated state.
http://science.sciencemag.org/
In this research, the team used Arabidopsis thaliana with mutations in a gene related to DNA methylation, and by confirming the instances of hybrid vigor, they investigated which genes and epigenetic modifications regulating the genes were linked to hybrid vigor.
This demonstrated that DDM1 and hybrid vigor are closely linked, and the epigenetic modification regulated by DDM1 (DNA methylation) is important in hybrid vigor.
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«The DNA methylation around these genes works like a container that ensures that H3K27me3, another epigenetic modification, which normally regulates these genes, is positioned correctly.»
The researchers linked the excess weight and changes in metabolism to epigenetic modifications that reduce expression of the gene for adiponectin — a hormone that helps regulate several metabolic processes, including glucose regulation.
Epigenetic modifications to DNA and histone proteins are known to regulate metabolic gene expression, which in turn impacts metabolite levels.
Epigenetic modifications are chemical changes to DNA that affect how genes are regulated.
Stroud was interested in studying epigenetic changes, or chemical modifications that turn genes on and off, in DNA for the glucocorticoid receptor gene that regulates passage of cortisol from mother to fetus.
Gene expression is regulated by epigenetic chemical modifications (including methylation and acetylation) on chromatin — histone proteins tightly associated with DNA.
Epigenetics are modifications on top of the DNA sequences and regulate expression of the DNA within each cell of the body as required for normal development and functioning.
Throughout the 2000s, Wistar scientists made seminal discoveries in the field of epigenetics and RNA transcription, contributing new knowledge on the role of histone modifications in gene regulation and DNA repair and how different RNA species, including microRNAs (miRNA) and long noncoding RNAs (lncRNA), are generated and how they regulate gene transcription.