Sentences with phrase «epigenetic modifications accumulated»
It has been long debated if epigenetic modifications accumulated throughout the entire life can cross the border of generations and be inherited to children or even grand children.
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Of course, that may be very dependent on the history of the cell, so the more mature a cell is the more it probably accumulated epigenetic modifications that sort of fix it in the valleys.
We have previously shown that epigenetic modifications may accumulate during aging (5,6), and that DNA methylation in humans is influenced by diet, birth weight, and exercise (7 — 10), suggesting that epigenetics could be involved in age - related and life style — related diseases such as T2D.