Sentences with phrase «epigenetic modifications associated»

Not exact matches

Epigenetics refers to biological processes — mostly biochemical modifications of the DNA and its associated proteins — that condition the expression or repression of genes.

«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.

Epigenetic modifications are chemical tags tacked onto DNA or associated proteins.

Gene expression is regulated by epigenetic chemical modifications (including methylation and acetylation) on chromatin — histone proteins tightly associated with DNA.

Since HIV infection itself alters epigenetic processes in the immune system, the research team wondered whether a distinct DNA methylation profile, a major epigenetic modification where methyl groups are added to DNA, occurs in those with HIV associated - cognitive impairment and whether it exists in distinct immune cell populations from the blood.

Recent studies have expanded the search for genetic links from identifying genes toward epigenetics, the study of factors that control gene expression and looks at chemical modifications of DNA and the proteins associated with it.

Epigenetics began as a correlative field in which covalent modifications to DNA or histones, the proteins that help package DNA, were associated with gene expression or silencing.

Interestingly, the most commonly mutated set of genes were those involved in epigenetic modification (25 % of tumors) followed by transcriptional regulators and MAP kinase - associated genes (12 - 15 %).

Epigenetic modification of chromatin includes methylation of genomic DNA as well as post-translational modification of chromatin - associated proteins, mainly histones.

What are the roles of aging - associated epigenetic modification in neuronal injury and inflammatory responses?