Sentences with phrase «epigenetic modifications at»
With the genome engineering revolution came epigenome - engineering tools - zinc finger nucleases and TALENs fused to epigenetic modifiers enabled epigenetic modifications at a user - specified locus.
http://blog.addgene.org/
It turns out in our works to date that we've been able to find epigenetic modifications at particular genes in emotional centers of the brain that mediate that resilience.
Not exact matches
De Assis, who presented the work at the American Association for Cancer Research meeting in Washington DC, says a fatty diet may cause «epigenetic» DNA modifications that can be passed on to future generations.
Researchers at the University of Zurich have now identified a mechanism how cells pass on the regulation of genetic information through epigenetic modifications.
As the researchers showed, already at the age of six weeks the Igfbp2 gene exhibited higher levels of methylation, i.e. stronger epigenetic modification, and at the same time the IGFBP2 synthesis in the liver was significantly reduced.
«Recent studies suggest that epigenetic modifications may contribute to the development of cancer progenitor cells that can induce drug resistance and the relapse of different types of cancer,» said Sibaji Sarkar, PhD, instructor of medicine at BUSM.
«This means that the epigenetic modifications are likely not caused by substances in the tobacco, but by the hundreds of different elements that are formed when the tobacco is burnt,» says Åsa Johansson, researcher at the Department of Immunology, Genetics and Pathology at Uppsala University and Uppsala Clinical Research Center, who has led the study.
Early results from a larger, ongoing study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst suggest that phthalate levels in expectant fathers have an effect on couples» reproductive success via epigenetic modifications of sperm DNA.
Schrock: I'm sure that's been tried, but one of the new things they found is this specific tie between the circadian rhythm in our bodies and drug addiction and they found that it is actually through an epigenetic modification of the circadian rhythm; so our circadian rhythms are reset by these drugs; we actually crave them at certain times of day and that is contributing to the necessity to, you know, relapse and go back on drugs or to get that craving, you know, at a certain point.
Martienssen, Couture, and Yannick Jacob, Ph.D., a postdoctoral fellow at CSHL and lead author on the paper, found that the key was a single epigenetic modification.
He and his team at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany used fruit flies to explore how epigenetic modifications are transmitted from the mother to the embryo.
Researchers based at Rice's Center for Theoretical Biological Physics (CTBP) have constructed computer models to analyze epigenetic marks, which include proteins bound to DNA as well as chemical modifications to histone proteins.
The TMWG kit incorporates Cambridge Epigenetix's TrueMethyl oxidative bisulfite (oxBS) technology, which allows researchers to accurately quantify different DNA modifications at single - base resolution, as well as proprietary library preparation methods designed to overcome the limitations of traditional bisulfite library construction, and to improve the yield and quality of epigenetic data.
The study is the first to establish a close link between epigenetic modifications on a cancer gene and the risk of developing the disease, says Robert Philibert, a behavioral geneticist at the University of Iowa in Iowa City.
Our next experiments will look more closely at epigenetic modifications within the thermogenesis signaling pathway so that we may manipulate it,» said Sakai.
Recent studies have expanded the search for genetic links from identifying genes toward epigenetics, the study of factors that control gene expression and looks at chemical modifications of DNA and the proteins associated with it.
AMHERST, Mass. — A new three - year, $ 440,000 study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst is now underway to investigate whether phthalate levels in expectant fathers have an effect on the couples» reproductive success, via epigenetic modifications of sperm DNA.
Xiaowei Zhuang, at Harvard University, and colleagues used super resolution microscopy to follow how chromatin packing changed based on its epigenetic modifications.
The main focus of her lab is the investigation of molecular mechanisms that lead to the erasure of epigenetic memory at both histone and DNA modification level.
Histone modifications at the blastocyst Axin1 (Fu) locus mark the heritability of in vitro culture - induced epigenetic alterations in mice
The overall goal of the core is to provide support to investigators interested in characterizing the interactions of post-translational modifications of histones (epigenetic marks that define a chromatin state or Epigenome) or transcription factors at specific genomic loci or genome - wide (Cistrome).
«Recent studies suggest that epigenetic modifications may contribute to the development of cancer progenitor cells that can induce drug resistance and the relapse of different types of cancer,» said Sibaji Sarkar, PhD, instructor of medicine at BUSM and the article's corresponding author.