Sentences with phrase «epigenetic modifications leading»
An example of epigenetic modifications leading to cancer progenitor cell formation possibly occurs in leukemia development.
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Scientists of the German Center for Diabetes Research (DZD) led by the German Institute of Human Nutrition (DIfE) have shown in a mouse model that the epigenetic * modification of the Igfbp2 ** gene observed in the young animal precedes a fatty liver in the adult animal later in life.
«This means that the epigenetic modifications are likely not caused by substances in the tobacco, but by the hundreds of different elements that are formed when the tobacco is burnt,» says Åsa Johansson, researcher at the Department of Immunology, Genetics and Pathology at Uppsala University and Uppsala Clinical Research Center, who has led the study.
Early results from a larger, ongoing study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst suggest that phthalate levels in expectant fathers have an effect on couples» reproductive success via epigenetic modifications of sperm DNA.
Martienssen, Couture, and Yannick Jacob, Ph.D., a postdoctoral fellow at CSHL and lead author on the paper, found that the key was a single epigenetic modification.
What's come out in recent years are findings that experiences in an adult organism can, through epigenetic modifications in the sperm and egg cells, be passed onto subsequent generations, leading to some provocative notions.
AMHERST, Mass. — A new three - year, $ 440,000 study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst is now underway to investigate whether phthalate levels in expectant fathers have an effect on the couples» reproductive success, via epigenetic modifications of sperm DNA.
The main focus of her lab is the investigation of molecular mechanisms that lead to the erasure of epigenetic memory at both histone and DNA modification level.
The quality and novelty of the data, leads to new insights into the replication landscape of the human genome and to further unravel the links between replication, gene expression, epigenetic modification and 3D genome organization in normal and cancer cells.