«Our results indicate that the
epigenetic modification we studied
makes both mice and humans more susceptible to obesity and with increasing age increases their risk of developing a fatty liver,» said Anne Kammel, first author of the study.
Throughout the 2000s, Wistar scientists
made seminal discoveries in the field of
epigenetics and RNA transcription, contributing new knowledge on the role of histone
modifications in gene regulation and DNA repair and how different RNA species, including microRNAs (miRNA) and long noncoding RNAs (lncRNA), are generated and how they regulate gene transcription.