Sentences with phrase «epigenetic modifications of»

Epigenetic modifications of promoter regions that influence the transcription of genes coding for crucial protein products can be induced by the environment.

Saturday, Oct. 21, 9:15 - 9:30 a.m., Room 220B, South Building Platform Presentation: Epigenetic modifications of innate immunity genes impact early - stage non-small cell lung cancer survival: An integrative analysis of epigenome and transcriptome in Caucasian population R. Zhang, Harvard T.H. Chan School of Public Health, et al

Toward the end of his postdoc, as a Helen Hay Whitney Foundation fellow, Dr. Lomvardas started working on DNA methylation and other epigenetic modifications of olfactory receptors.

AMHERST, Mass. — A new three - year, $ 440,000 study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst is now underway to investigate whether phthalate levels in expectant fathers have an effect on the couples» reproductive success, via epigenetic modifications of sperm DNA.

Disruption of a region in chromosome 6 or epigenetic modifications of the DNA block Sestrin1 expression and these contribute to the development of Follicular Lymphoma.

Nestler: The ability of this chronic social stress to produce maladaptive changes in brain and behavior are mediated through epigenetic modifications of gene expression in particular emotional centers of the brain.

What we found is that the ability of this chronic social stress to produce maladaptive changes in brain and behavior — loss of pleasure, inability to sleep normally and so on — are mediated through epigenetic modifications of gene expression, in particular, emotional centers of the brain.

Early results from a larger, ongoing study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst suggest that phthalate levels in expectant fathers have an effect on couples» reproductive success via epigenetic modifications of sperm DNA.

«For example, we now know that RNA can be methylated just like DNA and in a highly specific way,» says Dr. Manel Esteller, «and even more recently we observed that these epigenetic modifications of RNA may be key in the regulation of «guardian» RNAs, also called non-coding RNAs.»

«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.

In this way, certain epigenetic modifications of the histone tails are removed.

A study published this week in PLOS Medicine suggests that epigenetic modification of the HAND2 gene plays a critical role in the development of endometrial cancer.

Schrock: I'm sure that's been tried, but one of the new things they found is this specific tie between the circadian rhythm in our bodies and drug addiction and they found that it is actually through an epigenetic modification of the circadian rhythm; so our circadian rhythms are reset by these drugs; we actually crave them at certain times of day and that is contributing to the necessity to, you know, relapse and go back on drugs or to get that craving, you know, at a certain point.

Methylation is an epigenetic modification of DNA.

Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain

The article claimed the phenomenon was primarily driven by epigenetic modification of chromatin.

Epigenetic modification of chromatin includes methylation of genomic DNA as well as post-translational modification of chromatin - associated proteins, mainly histones.

Dissertation: «Epigenetic Modification of Vitamin D - induced Gene Expression in Human Colorectal and Breast Cancer Cell Lines.»

Postnatal epigenetic modification of glucocorticoid receptor gene in preterm infants: a prospective cohort study

Finally, animal research focusing on brain - structural aspects related to early care and the new, conceptually important direction of studying environmental programming of early development through epigenetic modification of gene functioning is examined in brief.

More recent research on the epigenetic modification of gene expression by early maternal care in animals suggests the possibility of similar processes affecting human development.

Not exact matches

Epigenetic changes, the chemical modifications of DNA that are the result of environmental influences, are the results of long term events lasting months or years, like famines.

Professor Keith Godfrey, from the Medical Research Council Lifecourse Epidemiology Unit and the National Institute for Health Research Southampton Biomedical Research Centre, and a member of the study team, said: «The new findings provide the first direct evidence linking faltering of a baby's growth in the womb with epigenetic modifications that themselves may increase the risk of childhood obesity.

These changes, known as epigenetic modifications, control the activity of our genes without changing the actual DNA sequence.

This method allows the scientists to measure very subtle effects with very high confidence, while eliminating the effect of any genetic or epigenetic modifications and cell culture related variations that could occur during the experiment.

Scientists of the German Center for Diabetes Research (DZD) led by the German Institute of Human Nutrition (DIfE) have shown in a mouse model that the epigenetic * modification of the Igfbp2 ** gene observed in the young animal precedes a fatty liver in the adult animal later in life.

Epigenetics refers to biological processes — mostly biochemical modifications of the DNA and its associated proteins — that condition the expression or repression of genes.

«Our findings point toward a previously unknown function of the DNMT3A protein in the interaction of these two epigenetic modifications that are normally not directly linked.

By contrast, in more than 90 % of endometrial cancers, the gene has undergone hypermethylation, an epigenetic modification that doesn't change its DNA sequence but renders it inactive.

These epigenetic modifications do not change the genetic code, but may contribute to the inhibition of gene expression, causing the cells to produce smaller amounts of the corresponding proteins.

Researchers at the University of Zurich have now identified a mechanism how cells pass on the regulation of genetic information through epigenetic modifications.

As the researchers showed, already at the age of six weeks the Igfbp2 gene exhibited higher levels of methylation, i.e. stronger epigenetic modification, and at the same time the IGFBP2 synthesis in the liver was significantly reduced.

«Our results indicate that the epigenetic modification we studied makes both mice and humans more susceptible to obesity and with increasing age increases their risk of developing a fatty liver,» said Anne Kammel, first author of the study.

Epigenetic effects include modification of DNA by incorporation of small chemical groups, methyl groups.

An example of epigenetic modifications leading to cancer progenitor cell formation possibly occurs in leukemia development.

«Recent studies suggest that epigenetic modifications may contribute to the development of cancer progenitor cells that can induce drug resistance and the relapse of different types of cancer,» said Sibaji Sarkar, PhD, instructor of medicine at BUSM.

Corin is particularly attractive as an inhibitor of epigenetic modifications because it has dual - target specificity which allows for more selective targeting of epigenetic complexes in treated cells.

BUSM researchers also discussed in Genetics & Epigenetics (May 2014) how epigenetic modifications play a role in the development of diseases including cancer, cardiovascular, metabolic, neurologic and pulmonary disorders.

A new study suggests that epigenetic effects — chemical modifications of the human genome that alter gene activity without changing the DNA sequence — may sometimes influence sexual orientation.

Epigenetic modifications do not affect the DNA sequence of genes, but change how the DNA is packaged and how genes are expressed.

The chemical modification of histones is thought to be a form of epigenetic information — information separate from our DNA — that controls gene regulation.

These new genes were created so they could not be the repositories of epigenetic tags or modifications.

The incoming paternal DNA contains modifications that facilitate an «epigenetic memory» of its sperm state.

«This means that the epigenetic modifications are likely not caused by substances in the tobacco, but by the hundreds of different elements that are formed when the tobacco is burnt,» says Åsa Johansson, researcher at the Department of Immunology, Genetics and Pathology at Uppsala University and Uppsala Clinical Research Center, who has led the study.

Later in life the genetic material can be changed by epigenetic modifications, i.e. chemical alterations of the DNA the affect the activity of the genes.

The researchers linked the excess weight and changes in metabolism to epigenetic modifications that reduce expression of the gene for adiponectin — a hormone that helps regulate several metabolic processes, including glucose regulation.

In addition to RNA transcripts linked with inflammation and stress, the study examines a series of epigenetic transcripts — RNA sequences that have undergone post-transcriptional modification.

He explains that cells could potentially lower their 19S subunit levels through a wide variety of epigenetic mechanisms, including microRNAs, transcription regulation, and histone modifications.

DNA methylation is one form of epigenetic modification being studied by scientists trying to understand how the same genetic code can produce so many different cells and tissues as well as differences between individuals as closely related as twins.

In order to elucidate the significance of early epigenetic modifications on the development of neural cells during embryogenesis in the mouse, Götz and her colleagues specifically inactivated the gene Uhrf1.