Sentences with phrase «epigenetic profiles»
«What these new findings on exhausted T cells tells us is that the unique epigenetic profile of exhausted T cells causes these cells to express a different overall set of genes compared to memory or effector T cells,» Wherry said.
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«Combined with the advancement of DNA sequencing technologies to capture epigenetic profiles in unique clinical samples, researchers can make discoveries that were previously not possible,» said Dr. Corley.
They identified progressive loss of DNA methylation in certain parts of the genome, and reported that memory T cells in the blood had distinct epigenetic profiles from those in the bone marrow.
High - throughput ChIP - Seq: One of the major questions for researchers interested in understanding chromatin dynamics is to investigate how protein - DNA interactions alter Epigenetic profiles and subsequent gene expression.
«We were surprised that the exhausted T cell epigenetic profile was not reprogrammed,» Wherry said.
«Using the NanoChIP - seq platform invented in Singapore, we created comprehensive epigenetic profiles for both GC and normal tissues,» explained team leader Professor Patrick Tan.
De Jager said that researchers are devising ways to eke out epigenetic profiles from single cells, which would ultimately simplify the comparison of different neuronal types.
«It can handle multiple biomarker technologies simultaneously, such as complex flow cytometry, next - generation sequencing, immunosequencing, epigenetic profiling, and other types of asssys measuring biological variation as well,» says Marshall.
It has been proposed that in response to a poor in - utero environment, an offspring's epigenetic profile will change.
The team found that exhausted T cells acquired an epigenetic profile distinct from effector or memory T cells.
«This report moves us a step closer when we will be able to prescribe a weight loss program tailored to more than just the lifestyle and conditioning level of the patient, but also to his or her particular genetic and epigenetic profile.»
Epigenetic profiles can be highly stable and confer long - term identity to a cell.
In this study, published in the journal Cell Reports, and led by Dr. Esteban Ballestar (IDIBELL), the comparison of the epigenetic profiles between dendritic cells and myeloid - derived suppressor cells has allowed them to identify the existence of specific epigenetic alterations that associated with the development of myeloid - derived suppressor cells as a result of exposure to prostaglandin E2.
«We predicted that exhausted T cells would not have a distinct epigenetic profile but have the molecular flexibility to obtain immune memory,» Wherry said.
By comparing the epigenetic profiles of gastric tumours to normal tissues from the same patient, we were able to identify those promoters specifically altered in GC tissues.»
To achieve this, we use large - scale genome scans including genome sequencing data, epigenetic profiling and molecular traits such as gene expression and metabolomics.
During Dutch famine, sex - dimorphic alterations of epigenetic profiles were seen in offspring exposed to malnutrition (Table 2)(155).
A number of recent articles, however, have reported that hiPSCs are, in fact, notably distinct from human embryonic stem cells in terms of their gene expression, epigenetic profile, proliferative capacity and the susceptibility of their differentiated progeny to cellular senescence and apoptosis [3 — 6].
Concurrently, the research group is examining how the epigenetic profile of different candidate genes predicts, and perhaps changes, in response to recovery from PTSD (and negative self - cognitions) along with its neural correlates.
Consumers will be able to receive actionable recommendations of optimized skincare products to use, as well as assess the progress of their skincare routines, based on their skin's epigenetic profiles.