Sentences with phrase «epigenetic profiles in»
HDAC inhibitors and decitabine are highly synergistic and associated with unique gene - expression and epigenetic profiles in models of DLBCL
http://www.haematologica.org/ Not exact matches
The Epigenetics Research group used these cells to perform genome - wide profiling across more than 20,000 individual genes in these patients.
In this study, published in the journal Cell Reports, and led by Dr. Esteban Ballestar (IDIBELL), the comparison of the epigenetic profiles between dendritic cells and myeloid - derived suppressor cells has allowed them to identify the existence of specific epigenetic alterations that associated with the development of myeloid - derived suppressor cells as a result of exposure to prostaglandin EIn this study, published in the journal Cell Reports, and led by Dr. Esteban Ballestar (IDIBELL), the comparison of the epigenetic profiles between dendritic cells and myeloid - derived suppressor cells has allowed them to identify the existence of specific epigenetic alterations that associated with the development of myeloid - derived suppressor cells as a result of exposure to prostaglandin Ein the journal Cell Reports, and led by Dr. Esteban Ballestar (IDIBELL), the comparison of the epigenetic profiles between dendritic cells and myeloid - derived suppressor cells has allowed them to identify the existence of specific epigenetic alterations that associated with the development of myeloid - derived suppressor cells as a result of exposure to prostaglandin E2.
By comparing the epigenetic profiles of gastric tumours to normal tissues from the same patient, we were able to identify those promoters specifically altered in GC tissues.»
Since HIV infection itself alters epigenetic processes in the immune system, the research team wondered whether a distinct DNA methylation profile, a major epigenetic modification where methyl groups are added to DNA, occurs in those with HIV associated - cognitive impairment and whether it exists in distinct immune cell populations from the blood.
«Using the NanoChIP - seq platform invented in Singapore, we created comprehensive epigenetic profiles for both GC and normal tissues,» explained team leader Professor Patrick Tan.
The fact that she has found them to be differentially regulated in angiosarcoma tumors has led to the hypothesis that there are epigenetic regulators of these genes that have yet to be identified through the genomic profiling applied to these studies thus far.
During Dutch famine, sex - dimorphic alterations of epigenetic profiles were seen in offspring exposed to malnutrition (Table 2)(155).
Nevertheless, our knowledge about the role of epigenetics in the growing incidence of T2D remains limited, and the genome - wide expression profile has, to our knowledge, not been linked to the epigenome in adipose tissue of diabetic patients.
A number of recent articles, however, have reported that hiPSCs are, in fact, notably distinct from human embryonic stem cells in terms of their gene expression, epigenetic profile, proliferative capacity and the susceptibility of their differentiated progeny to cellular senescence and apoptosis [3 — 6].
Concurrently, the research group is examining how the epigenetic profile of different candidate genes predicts, and perhaps changes, in response to recovery from PTSD (and negative self - cognitions) along with its neural correlates.
Molaro, A. and Hodges, E. and Fang, F. and Song, Q. and McCombie, W. R. and Hannon, G. J. and Smith, A. D. (2011) Sperm Methylation Profiles Reveal Features of Epigenetic Inheritance and Evolution in Primates.
High - throughput ChIP - Seq: One of the major questions for researchers interested in understanding chromatin dynamics is to investigate how protein - DNA interactions alter Epigenetic profiles and subsequent gene expression.
The risk profile has a strong basis in epigenetics — the influence of diet and lifestyle on how particular genotypes are expressed.
«We're really trying to learn through molecular profiling analysis and a lot of epigenetic changes how to beat cancer, but not beat the patient's brain in the process,» he says.
For example, prenatal maternal anxiety is associated with an altered function of the placenta, in a way that may allow more cortisol to pass from mother to fetus.8 This probably underlies some of the alterations in fetal and child brain neurodevelopment following early exposure to stress and may also be one of the mediators of an altered epigenetic profile, although many other biological systems, including serotonin, dopamine and the pro-inflammatory cytokines, are also likely to be involved.