Sentences with phrase «epigenetic regulation»
"Epigenetic regulation" refers to the control or influence of gene activity without changes to the underlying DNA sequence. It involves modifications to the structure or packaging of genes, which affects how they are expressed or function. Essentially, it's like switching on or off certain genes without actually altering their DNA code. Full definition
Protein complexes, epigenetic regulation of gene expression and cancer.
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Results of animal work can not be translated directly to humans, but initial findings of recent research suggest an effect of parental care on epigenetic regulation in the human brain.
My long - term career goal is to lead a successful independent academic lab studying how epigenetic regulation contributes to normal biology and disease pathology, particularly in repeat diseases.
His group specialises in the study of the genetic and epigenetic regulation of female germ cell development.
Recently there have been multiple reports that hybrid vigor is influenced by epigenetic regulation as well as genetics.
This altered expression that does not correlate with changes in the base sequence is known as epigenetic regulation (as opposed to genetic regulation).
«While scientists all around the world are working on developing new drugs using NK cells, none of the drugs in development focuses on epigenetic regulation of the cells.
«Our findings suggest that molecular mechanisms for epigenetic regulation within the spinal cord constitute the starting point for handedness,» said Ocklenburg from Ruhr University Bochum in Germany.
In their new paper, Reh and his colleagues show that, by using a drug that blocks epigenetic regulation called a histone deacetylase inhibitor, activation of Ascl1 allows the Müller glia in adult mice to differentiate into functioning interneurons.
01/29/2015: New paper on tissue - specific genetic & epigenetic regulation with Gutierrez - Arcelus et al. in PLoS Genetics
Rather the opposite was true, the altered epigenetic regulation of the gene was responsible for the development of the fatty liver,» added Sophie Saussenthaler, who shared the first authorship with Baumeier.
«Our study connects the dots between Werner syndrome and heterochromatin disorganization, outlining a molecular mechanism by which a genetic mutation leads to a general disruption of cellular processes by disrupting epigenetic regulation,» says Izpisua Belmonte.
«Epigenetic regulation required to ensure correct number of chromosomes.»
In this case, via epigenetic regulation of the glutocorticoid receptor gene.
3) This finding also reveals the possibility that maternal small - noncoding RNAs participate in fetal epigenetic regulation during pregnancy.
Williams K, Seiss K, Beamon J, Pereyra F, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M. Epigenetic regulation of telomerase expression in HIV -1-specific CD8 + T cells.
Second, the promoters of the PTPN6 and miR - 200c / 141 transcription units physically interact through a 3 - dimensional DNA loop and exhibit similar epigenetic regulation.
In this session, we will describe current progress in exploring the pathogenic sequence in these disorders using high throughput methods, the discovery of relevant target genes, and the use of agents to modify epigenetic marks in an effort to ameliorate ongoing problems relating to defective epigenetic regulation.
Dynamic epigenetic regulations of the Gdnf gene play significant roles in identifying both the susceptibility and the adaptation responses to chronic stressful events.
Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain - derived neurotrophic factor expression
Further work on epigenetic regulators in eukaryotes will be accompanied by advanced engineering strategies to examine roles of epigenetic regulation in mammalian development, stem cells, ageing and disease.
Previously, Dr. Ray completed her PhD at Harvard University with Dr. Robert Kingston, studying the effects of long non-coding RNAs on epigenetic regulation.
«Because of this, animals likely have a greater requirement for epigenetic regulation than yeast do,» Matera said.
Instead, viruses mute the immune system by epigenetic regulation — instead of changing the actual code of genes, viruses change the degree to which genes are expressed.
Protein methyltransferases (PMTs) play essential roles in epigenetic regulation of gene expression and chromatin dependent signaling via their methylation of histones and other chromatin associated substrates.
«The whole of epigenetic regulation may be greater than the sum of its parts.»
«These new insights into the complexities of epigenetic regulation are contributing to our basic understanding of this process in human health and disease and gives us new vision for how to go about targeting errors in DNA methylation with innovative drug therapies.»
For 50 years, the fundamental principles and mechanisms of the epigenetic regulation of gene expression have been explored across myriad organisms and human diseases.
Therefore, toxicologists who research health, exposure - related disease, and susceptibility are actually concurrently studying the consequences of epigenetic regulation.
The data from the study demonstrate that KZFP partner up with transposable elements to create what the authors call «a largely species - restricted layer of epigenetic regulation.»
The best - studied form of epigenetic regulation is methylation, the addition of clusters of atoms made of carbon and hydrogen (methyl groups) to DNA.
Already, Surani's and Hanna's groups have used the artificial PGCs to investigate the role of individual enzymes in epigenetic regulation, which may one day show how the epigenetic networks are involved in disease.
One type of epigenetic regulation is caused by changes to the shape of complexes called chromatin, the bundles of DNA and certain fundamental proteins that make up the chromosomes.
The fact that a thousand proteins are involved in epigenetic regulation is pretty astounding, because that's just a genes wrapped up in controlling genes.
This is the first study to demonstrate an epigenetic model of nitric oxide signaling that has the potential to «change our fundamental understanding of both nitric oxide biology and epigenetic regulation,» Thomas said.
It is a form of epigenetic regulation — the control of how and when parts of the genome operate.
DNA methylation has been held up as one example of epigenetic regulation.
The methylation of CpG sites is a fundamental form of epigenetic regulation that occurs throughout the body.
This study represents a step forward in understanding the underlying mechanisms of T - cell function and epigenetic regulation of the HDAC11 enzyme.
Citation: Kauder SE, Bosque A, Lindqvist A, Planelles V, Verdin E (2009) Epigenetic Regulation of HIV - 1 Latency by Cytosine Methylation.
Chromatin structure contributes to the epigenetic regulation of gene expression, DNA replication or DNA repair.
Full citation Nature, early online edition, August 15, 2004 «Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits» Authors: Heather L. True (1), Ilana Berlin (2), Susan L. Lindquist (2)
He is currently an associate professor at the KAIST in Korea, where his group is working on determining the atomic structure of chromatin modifying complexes in order to understand mechanisms of epigenetic regulation.