Research Focus: I dedicate my time and effort to develop high - throughput sequencing technologies such as single cell transcriptomic, ChIP - Seq, ChIA - PET, and many more... The scientific rational is to understand better and with a different angle, the mechanisms of
epigenetic regulation of gene expression in (rare) immune cells, pathologically relevant in many diseases such as asthma, SLE, tuberculosis...
The isoforms of this histone play complex regulatory roles in several cellular processes —
epigenetic regulation of gene expression, selective regulation of developmental genes, and telomere maintenance — that could contributed to tumor growth and progression if dysregulated.
Protein complexes,
epigenetic regulation of gene expression and cancer.
Chromatin structure contributes to
the epigenetic regulation of gene expression, DNA replication or DNA repair.
Rather the opposite was true, the altered
epigenetic regulation of the gene was responsible for the development of the fatty liver,» added Sophie Saussenthaler, who shared the first authorship with Baumeier.
For 50 years, the fundamental principles and mechanisms of
the epigenetic regulation of gene expression have been explored across myriad organisms and human diseases.
Not exact matches
The evidence for
epigenetic effects on emotion
regulation is quite solid: Early caregiving experiences can affect the expression
of the
genes that regulate a baby's stress and they can shape how the endocrine system will mobilize to stress.
Epigenetic mechanisms give tortoiseshell cats their markings, but are also involved in our development in the womb and the day - to - day
regulation of our
genes
There already has been great effort to elucidate the mechanisms
of gene expression
regulation, but it will be important to continue research to fully realize the potential
of these
epigenetic therapies and their applications in clinical settings.
Beverly A. Purnell Senior Editor Education: B.S., Shepherd College; M.S., Ph.D., The Pennsylvania State University Areas
of responsibility: Developmental biology,
gene regulation, stem cells, reproductive biology, molecular biology,
epigenetics E-Mail:
[email protected]
The chemical modification
of histones is thought to be a form
of epigenetic information — information separate from our DNA — that controls
gene regulation.
The researchers linked the excess weight and changes in metabolism to
epigenetic modifications that reduce expression
of the
gene for adiponectin — a hormone that helps regulate several metabolic processes, including glucose
regulation.
Epigenetic changes do not alter the structure
of the DNA, but they do change the way the DNA is modified, which subsequently determines the potential
of gene regulation.
Instead, viruses mute the immune system by
epigenetic regulation — instead
of changing the actual code
of genes, viruses change the degree to which
genes are expressed.
Methyl labels in the DNA play a key role in this «
epigenetic»
regulation of gene activity.
Hypermethylation
of DNA is a key
epigenetic mechanism for the silencing
of many
genes, including those for cell cycle
regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).
Epigenetics involves the
regulation of genomic functions, including
gene expression.
His fundamental work has provided novel insights into the mechanisms
of epigenetic gene regulation.
Studies could include examining the activation and deactivation
of genes (e.g., transcription factors or
epigenetic regulation) or involve more classical genetic identification studies.
Researchers have identified a host
of factors involved in
epigenetic control
of gene expression and development, but many
of the precise mechanisms underlying this type
of regulation remain unclear.
The Sarma laboratory is interested in the mechanisms
of epigenetic gene regulation, or how the dynamic modifications
of the architecture
of chromatin, the complex
of DNA and proteins within the nucleus
of our cells, impacts
gene expression and cellular function.
Through this packaging mechanism, researchers think that histone proteins are the key to regulating access to the genetic information by making different parts
of the DNA accessible to factors that express the
gene, so - called
epigenetic regulation.
We found that
genes within islands
of differentiation were enriched for several functional classes (Table S4), and most terms were related to transcription and
epigenetic pathways (e.g. chromatin organization and modification,
regulation of transcription and translation, DNA binding).
Her scientific expertise lies in understanding the
epigenetic basis
of gene regulation during embryonic development and disease ontology.
The
gene content
of these regions, which in several cases reached
gene - level resolution, suggests an important role for
epigenetic and transcription
regulation in the maintenance
of reproductive barriers.
This observation and the availability
of a reference rabbit genome allowed us to identify several candidate
genes for reproductive isolation in this system that suggest an important role for
epigenetic and transcription
regulation in the maintenance
of reproductive barriers.
Xu is developing computational algorithms for the design and analysis
of high - throughput biological experiments with a focus on applications in transcriptional and
epigenetic gene regulation.
Although the mechanism
of age - related decline in DNA repair capacity is unknown, growing evidence suggests that
epigenetic events (e.g., DNA methylation) contribute to the ageing process and may be functionally important through the
regulation of the expression
of DNA repair
genes.
The afternoon
of the second day focused on somatic changes in melanoma, that is changes that occur in the tumour itself, and this session saw talks from ESR07 Sofia Chen on the mutational landscape
of primary melanoma tumours; ESR08 Catarina Salgado on DNA hydroxymethylation (a form
of regulation) in melanoma and naevi; and ESR10 Adriana Sanna on
epigenetic regulation (reversible changes to the DNA which can turn
genes on / off)
of melanoma cell phenotypes.
Professor Dockrell and her group are investigating mechanisms that regulate the production
of immune - related proteins, starting from
gene regulation (
epigenetics),
gene expression (transcriptomics), cell phenotypes (flow cytometry) and finally protein release.
We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression
of some
genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers
of epigenetic gene silencing through the
regulation of the transcription
of specific
genes, which involves changes in the chromatin state.
Throughout the 2000s, Wistar scientists made seminal discoveries in the field
of epigenetics and RNA transcription, contributing new knowledge on the role
of histone modifications in
gene regulation and DNA repair and how different RNA species, including microRNAs (miRNA) and long noncoding RNAs (lncRNA), are generated and how they regulate
gene transcription.
How does
regulation of gene expression determine inner ear function on a genetic and
epigenetic level?
Dynamic
epigenetic regulations of the Gdnf
gene play significant roles in identifying both the susceptibility and the adaptation responses to chronic stressful events.
We want to understand this observation through the investigation
of gene regulation in the context
of the
epigenetic landscape.