Sentences with phrase «epigenetic regulators»

We apply advanced reverse genetic strategies, some of which were developed by us, to analyze select classes of epigenetic regulators in both organisms.

This activation is achieved by proteins called epigenetic regulators, which work to make specific regions of our genome more or less accessible to transcription.

Further work on epigenetic regulators in eukaryotes will be accompanied by advanced engineering strategies to examine roles of epigenetic regulation in mammalian development, stem cells, ageing and disease.

The field of cancer epigenetics was recently transformed by the finding that genes encoding for epigenetic regulators are among the most commonly mutated genes in human cancers.

«Multiple epigenetic regulators participate in the drug - desensitizing pathway, so they could serve as new targets to improve therapy for this type of cancer.»

Rett syndrome is a neurodevelopmental disorder that is caused primarily by mutations in the gene encoding for MeCP2, an important epigenetic regulator.

The three Group 3 medulloblastoma cell lines used in this study reinforced the observation, highlighting significant differences in epigenetic regulators at work in medulloblastoma cell lines versus tumor samples.

Because epigenetic regulators and chromatin - associated proteins are often tractable drug targets, my laboratory actively seeks to discover new targets and translate our findings into novel therapeutics for cardiovascular disease.

Discovered that BET bromodomain epigenetic regulators function as critical drivers of heart failure pathogenesis and vascular injury responses that can be pharmacologically targeted in vivo

Diana Hargreaves studies a particular epigenetic regulator, the SWI / SNF complex, which uses energy to unpack and unwind DNA from structural proteins to alter DNA accessibility and in turn, gene transcription.

In yeast, we are using protein - tagging and mass spectrometry to characterize complexes containing epigenetic regulators.

Many other molecules are also involved in this process, including epigenetic regulators that help to densely pack the genome into the nucleus of a cell, or locally unpack it to allow gene expression.

E. Korb et al. «Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Bd4 Inhibition,» Cell 170 (September 7, 2017): 1209 - 1223.

Identification of new factors, genes or epigenetic regulators involved in heart repair might ultimately aid to improve cardiac integrity upon damage to maintain a better cardiac function after an infarct.

«Through this assessment of epigenetic regulators, we identified PRMT1 as a top scoring «hit» in these patient - derived tumors,» said Virginia Giuliani, Ph.D., senior research scientist, IACS.

His team's previous work had hinted that FMRP controls a group of proteins called epigenetic regulators.

Co-first author, Dr Stephen Clark, a post-doctoral researcher at the Babraham Institute, said: «Methods for studying gene expression or epigenetic regulators in individual cells are quite established.

Durect, Corp., a biopharmaceutical company developing therapeutics based on its epigenetic regulator program and proprietary drug delivery platforms, posted an all - time low of 61 cents in November 2012 before embarking on an uptrend that topped out at $ 3.42 in June 2015.

Schüle and his team have already conducted well - known studies on the epigenetic regulator LSD1.

One of these, a novel inhibitor of the epigenetic regulator KDM4, co-developed in the lab of Prof. Schüle, showed promising results.

Scientists from the cluster of excellence BIOSS Centre for Biological Signalling Studies at the University of Freiburg and the Freiburg University Medical Center have shown that inhibiting the epigenetic regulator KDM4 might offer a potential novel treatment option for breast cancer patients.

Now, they have discovered that an inhibitor of the epigenetic regulator KDM4 shows great promise in modulating breast cancer stem cell pathology.

The drug, lapatinib, activates the suppressor called FOXO, in HER2 + breast cancer cells, but then FOXO becomes a turncoat molecule, working with an epigenetic regulator that controls gene expression.

Researchers used the analytic tool ChiP - seq to identify and track medulloblastoma subtype differences based on the activity of epigenetic regulators.

Sandra Lubitz (Stewart, TUD)-- «Analysis of an epigenetic regulator in mouse embryonic stem cell - Self - renewal and differentiation» (2005)

The fact that she has found them to be differentially regulated in angiosarcoma tumors has led to the hypothesis that there are epigenetic regulators of these genes that have yet to be identified through the genomic profiling applied to these studies thus far.

Central in this approach are the Polycomb Group proteins, a class of epigenetic regulators that control chromatin structure and have been implicated both in normal and abnormal development.

I graduated with my thesis on «Epigenetic regulators in normal and malignant development of skin» while working with Prof.Dr.Karin Scharffetter - Kochanek.

Tet2 is a type of cellular enzyme known as an epigenetic regulator — responsible for making specific chemical annotations to regions of DNA that alter the activity of many different genes.

The researchers say they've found evidence that obesity changes the microRNA (miRNA) signature — epigenetic regulators of gene expression — in both the dad's sperm and the daughter's breast tissue, suggesting that miRNAs may carry the epigenetic information from obese dads to their daughters.

Michelle Barton, Ph.D., was nominated and elected by her scientific peers in recognition for her contributions to understanding the function of the tumor suppressor, p53 in stem cells, particularly with respect to the discovery of TRIM24, an E3 - ligase and epigenetic regulator that is overexpressed in many cancers.