Sentences with phrase «epigenetic regulators in»

We apply advanced reverse genetic strategies, some of which were developed by us, to analyze select classes of epigenetic regulators in both organisms.

I graduated with my thesis on «Epigenetic regulators in normal and malignant development of skin» while working with Prof.Dr.Karin Scharffetter - Kochanek.

Co-first author, Dr Stephen Clark, a post-doctoral researcher at the Babraham Institute, said: «Methods for studying gene expression or epigenetic regulators in individual cells are quite established.

Not exact matches

Durect, Corp., a biopharmaceutical company developing therapeutics based on its epigenetic regulator program and proprietary drug delivery platforms, posted an all - time low of 61 cents in November 2012 before embarking on an uptrend that topped out at $ 3.42 in June 2015.

The field of cancer epigenetics was recently transformed by the finding that genes encoding for epigenetic regulators are among the most commonly mutated genes in human cancers.

«Through this assessment of epigenetic regulators, we identified PRMT1 as a top scoring «hit» in these patient - derived tumors,» said Virginia Giuliani, Ph.D., senior research scientist, IACS.

One of these, a novel inhibitor of the epigenetic regulator KDM4, co-developed in the lab of Prof. Schüle, showed promising results.

Now, they have discovered that an inhibitor of the epigenetic regulator KDM4 shows great promise in modulating breast cancer stem cell pathology.

The drug, lapatinib, activates the suppressor called FOXO, in HER2 + breast cancer cells, but then FOXO becomes a turncoat molecule, working with an epigenetic regulator that controls gene expression.

«Multiple epigenetic regulators participate in the drug - desensitizing pathway, so they could serve as new targets to improve therapy for this type of cancer.»

Rett syndrome is a neurodevelopmental disorder that is caused primarily by mutations in the gene encoding for MeCP2, an important epigenetic regulator.

The three Group 3 medulloblastoma cell lines used in this study reinforced the observation, highlighting significant differences in epigenetic regulators at work in medulloblastoma cell lines versus tumor samples.

Discovered that BET bromodomain epigenetic regulators function as critical drivers of heart failure pathogenesis and vascular injury responses that can be pharmacologically targeted in vivo

The fact that she has found them to be differentially regulated in angiosarcoma tumors has led to the hypothesis that there are epigenetic regulators of these genes that have yet to be identified through the genomic profiling applied to these studies thus far.

Diana Hargreaves studies a particular epigenetic regulator, the SWI / SNF complex, which uses energy to unpack and unwind DNA from structural proteins to alter DNA accessibility and in turn, gene transcription.

In yeast, we are using protein - tagging and mass spectrometry to characterize complexes containing epigenetic regulators.

Many other molecules are also involved in this process, including epigenetic regulators that help to densely pack the genome into the nucleus of a cell, or locally unpack it to allow gene expression.

The researchers say they've found evidence that obesity changes the microRNA (miRNA) signature — epigenetic regulators of gene expression — in both the dad's sperm and the daughter's breast tissue, suggesting that miRNAs may carry the epigenetic information from obese dads to their daughters.

Michelle Barton, Ph.D., was nominated and elected by her scientific peers in recognition for her contributions to understanding the function of the tumor suppressor, p53 in stem cells, particularly with respect to the discovery of TRIM24, an E3 - ligase and epigenetic regulator that is overexpressed in many cancers.

Interestingly, the most commonly mutated set of genes were those involved in epigenetic modification (25 % of tumors) followed by transcriptional regulators and MAP kinase - associated genes (12 - 15 %).

We applied our technology to several epigenetic regulators, recovering bi-allelic targeted clones with a high efficiency of 60 % and used Flp recombinase to restore expression in two null cell lines to demonstrate how our system confirms causality through mutant phenotype reversion.

Next up was Didier Trono who talked about how transposable elements and their epigenetic control mechanisms are key regulators of transcriptional networks in PSCs.