Sentences with phrase «epigenetic reprogramming by»

Not exact matches

The researchers identified a surveillance mechanism that not only monitors DNA lesions caused by epigenetic reprogramming but also fixes the damage.

As explained by lead researcher, Dr Ferdinand von Meyenn, postdoctoral researcher in the Epigenetics research programme at the Babraham Institute and first author on the paper: «Our method establishes a reliable system that can be used to explore the early stages of epigenetic reprogramming in primordial germ cell - like cells and how this is regulated in the generation of reproductive cells.

The two genomes are marked by distinct epigenetic modifications acquired during reprogramming.

The ultimate goal is to precisely understand the mechanisms of checkpoint blockade effectiveness and bring next generation, sustainable immunotherapies to even more patients, perhaps using by using epigenetic drugs in combination with checkpoint blockade to allow epigenetic reprogramming of exhausted T cells into durable and functional memory T cells.

So this actually connects me to the next question by Ohud, and the question was: What are exactly the epigenetic barriers that might be responsible for interfering with reprogramming?

Since the in vitro reprogramming systems are characterised by very low efficiency Petra's lab focuses on the systems where epigenetic reprogramming occurs naturally as a part of normal embryonic development.

These two observations suggest that worker reproduction is influenced by more plastic epigenetic processes than those of queen — worker differentiation — processes, it has been suggested, that could be analogous to somatic cell reprogramming and transdifferentiation [36].