Sentences with phrase «epigenetic signatures»

-- We have identified epigenetic signatures that separate patient groups depending on different disease outcome.

But the new data showing that a large fraction of epigenetic signatures of ethnicity reflect something other than ancestry suggests that abandoning the idea of race and ethnicity altogether could sacrifice a lot of valuable information about the drivers of differences in health and disease between different communities.

For example, although Cooper's team successfully read methylation from a fossil bison specimen, they could not find a signal in five other bison fossils they examined, which suggests that reading ancient epigenetic signatures requires exceptional preservation.

Citation: McGowan PO, Suderman M, Sasaki A, Huang TCT, Hallett M, Meaney MJ, et al. (2011) Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats.

«Our next step will be to understand how specific epigenetic signatures are linked to particular environmental exposures, and use those signals to understand patient risk.»

In the new study, published in Human Molecular Genetics, researchers analyzed epigenetic signatures in blood cells from 374 individuals enrolled in the European Prospective Investigation into Cancer and Nutrition.

Collaborating with the labs of Salk Professors Joseph Ecker and Alan Saghatelian, the Izpisua Belmonte team performed extensive characterization of the new cells and found rsPSCs showed distinct molecular and metabolic characteristics as well as novel epigenetic signatures — that is, patterns of chemical modifications to DNA that control which genes are turned on or off without changing the DNA sequence.

Greenwood Genetic Center (GGC) researchers in collaboration with scientists from Canada have identified unique epigenetic signatures for nine neurodevelopmental disorders lending to a better method of diagnosis for disorders with much clinical overlap.

Epigenetic signatures in older cells — patterns of chemical marks on DNA that dictate what genes are expressed when — were reset to match younger signatures in the process.

Ancient epigenetic signatures could help.

Broad epigenetic signature of maternal care in the brain of adult rats.

The researchers hypothesized that by comparing the «epigenetic signature» of healthy people's HSCs with that of AML patients» cancerous white blood cells, they could predict survival of AML patients.

Researchers from UCL (University College London) identified an epigenetic signature in the blood of women predisposed for breast cancer owing to an inherited genetic mutation of the BRCA1 gene.

Further research needs to be done to find out whether this epigenetic signature is just an indicator of breast cancer risk or is involved with the progression of breast cancer.

Professor Martin Widschwendter, the study's lead author and Head of University College London's Department of Women's Cancer says: «We identified an epigenetic signature in women with a mutated BRCA1 gene that was linked to increased cancer risk and lower survival rates.

The researchers believe the epigenetic signature they found is consistent with the idea that changes in the epigenome of immune cells are key to cancer progression.

Next, they extracted the DNA from developing and mature heart cells, using an advanced gene - sequencing technique called ChIP - seq that lets scientists «see» the epigenetic signatures written in the DNA.

The «prevailing view» is that iPSCs and cells differentiated from them will better model aging - related diseases if they retain their epigenetic signature of aging, he said.

City of Hope is home to diabetes experts from all over the world, who are studying genetic and epigenetic signatures in patients, using data from the most well - known, longest - ranging diabetes clinical trial.