Sentences with phrase «epigenetic silencing»
"Epigenetic silencing" refers to the process in which certain genes in our DNA are effectively switched off or deactivated. It occurs when certain chemical modifications are added to our DNA or the proteins that package our DNA, resulting in these genes not being expressed or used to create proteins. This can have significant effects on how our cells function and can contribute to the development of various diseases or other biological changes in our body. Full definition
These two histones thus have a key role of epigenetic silencing of tumor suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets.
massgenomics.org
Six speakers were ultimately selected to represent the next generation of cancer researchers, including GMI's very own Angela Ting for her work on RNA - mediated epigenetic silencing in human cancers.
SQLE increased the NADP + / NADPH (reduced form of NADP +) ratio, which triggered a cascade of events involving oxidative stress — induced DNA methyltransferase 3A (DNMT3A) expression, DNMT3A - mediated epigenetic silencing of PTEN, and activation of AKT - mTOR (mammalian target of rapamycin).
The pathway they describe acts as a fail - safe to prevent transposon damage when epigenetic silencing is lost.
Dallosso AR, Øster, B, Greenhough A, Thorsen K, Curry TJ, Owen C, Hancock AL, Szemes M, Paraskeva C, Frank M, Andersen CL, Malik K. Long - range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways.
Her graduate work culminated in multiple publications in the field of cancer epigenetics and in a thesis entitled «Aberrant epigenetic silencing of tumor suppressor genes in human cancer: the roles of DNA hypermethylation and the histone code.»
This happens by epigenetic silencing of the other copy, where specific marks on the DNA carry a memory of whether a gene sitting on a copy of a chromosome came from the sperm or the egg.
Finally, the allelome offers a near complete picture of «genomic imprinting,» the process that leads to epigenetic silencing of either the maternal or paternal allele that is initiated by an epigenetic mark placed in either the egg or sperm.
«Epigenetic silencing of tumor suppressor promotes endometrial cancer.»
Epigenetic silencing of the p16 (INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary.
The epigenetic silencing of p57KIP2 and KvLQT1 is achieved by switching maternal epigenotype into paternal epigenotype as manifested by the biallelic expression of LIT1 and loss of methylation of the CpG island on the maternal chromosome Interesting, LOI of LIT1 was not associated with LOI of IGF2.
Our recent work suggests that epigenetic silencing of p57KIP2 and KvLQT1 by an antisense RNA located in the intron of KvLQT1 gene occur frequently in BWS patients (1).
Reference: Nature, «Epigenetic silencing of Th1 type chemokines shapes tumor immunity and immunotherapy,» published online Oct. 26, 2015
Conclusion: some babies are getting off to a bum start in life due to epigenetic silencing of an important gene.