And we are gaining more and more information as to how the drugs actually interact with that
preexisting epigenetic state to lead to an addiction syndrome.
We have identified novel polymorphic variation that
modifies epigenetic states, genome - wide expression levels, and reproductive phenotypes.
The integration of multi-scale knowledge and data is strongly encouraged including the analysis of gene expression, epigenetics, physiological function, pathological states, and drug and small molecule effects as a function of genetic and environmental and
epigenetic state alterations.
These nutrients regulate
the epigenetic state of the embryo.
The drug had no effect on
the epigenetic state of DNA taken from the local metastasis but reversed the epigenetic changes seen in cells from the distant metastasis.
A mother's low protein diet while pregnant is therefore likely to have more severe consequence on the offspring's
epigenetic state and weight than an offspring's own diet after it has been weaned.
Marlinde L. van den Boogaard conduct analyses suggesting transcription of DUX4 in somatic cells is modified by variations in
its epigenetic state and provide a basis for understanding the reduced penetrance of Facioscapulohumeral dystrophy (FSHD) within families.
Various genomic structures and
epigenetic states are known to shape and modify mutational landscapes across genomes [64].
Silvana Konermann et al. «Optical control of mammalian endogenous transcription and
epigenetic states.»
For example, a recent study demonstrates differences in
the epigenetic state (as evidenced by DNA methylation) of the Monoamine Oxidase A gene across Beagles, German Shepherds, and Sapsaree Dogs.