We find that reducing the amount
of epigenetic variation available to populations can reduce adaptation in environments where it otherwise happens.
Dr. Vijayanand also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how
epigenetic variations cause susceptibility to disease.
In particular, the goals are to investigate
patient epigenetic variation that influences the response to immunotherapy and to use epigenetic therapeutics alone or in combination with immunotherapy to inhibit tumor progression as well as to overcome resistance to immunotherapy.
Subsequently, I'm managing a large - scale, genome - wide study on gene expression and epigenetic markers in various types of human immune cells, which will aid the understanding
of epigenetic variations that cause the susceptibility to disease.
Vijay also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how
epigenetic variations cause susceptibility to disease.
His group are in interested in generating new variation through interspecific hybridizations and induced polyploidy to support crop improvement strategies and are examining the potential of
epigenetic variation.
The epigenetic variation at MEs is determined randomly and is influenced by many environmental factors, ranging from the nutritional breakdown of the mother's diet to the season.
It aims to catalog not just cell types — which are predicted to extend far beyond the 200 types most often cited in textbooks — but also the hallmarks of cell types under different conditions and in individuals with different genetic and
epigenetic variations.
Some of
the epigenetic variation that occurs between identical twins is likely because of random changes, says Nessa Carey.
Such differences in neurobiological sensitivity, likely based, in part, on genetic and
epigenetic variation, are figuring prominently in the field's exploration of the biological embedding of early stress.