Sentences with phrase «epigenome using»

They then comprehensively analyzed the changes in the whole genome and epigenome using next generation deep sequencing.

The research groups then examined the landscape of the pancreatic cancer epigenome using a combination of stains on patient tissues, direct examination of the proteins that wrap DNA and whole - genome sequencing of the detected epigenetic changes to map precisely where they were located.

Not exact matches

To make things more complex, there's the epigenome — the chemical modifications to DNA that help control which genes are turned on and off — and the transcriptome, the full range of RNAs that translate DNA's blueprints so they can be used to make proteins.

Aware that cancers rewire their metabolism in ways that could change the epigenome and that distant metastases in pancreatic cancer naturally spread to organs fed by a sugar - rich blood supply, the researchers wondered if the tumor cells had altered the way they use the basic form of sugar, glucose.

Several medications that work by altering the epigenome are already in use.

While the transgenic method can not be used to study epigenetics in people, Philip de Jager of Brigham and Women's Hospital in Boston said Nathans's work established the extent to which epigenomes of neurons vary, and will pave the way for technological advances in human studies.