Sentences with word «epigenomic»

The mission of Epigenomics Profiling core is to actively participate and contribute to the growing Epigenetics community at the University of Texas M.D. Anderson Cancer Center (UTMDACC) by providing services to analyze alterations to chromatin such as, DNA methylation and DNA - bound protein modifications (ChIP).

Epigenomic profiling of complex tissues obscures regulatory elements that distinguish one cell type from another, researchers report.

In 2008 the National Institutes of Health launched the $ 190 - million Roadmap Epigenomics Project with the goal of cataloguing the epigenetic marks in the major human cell types and tissues.

The researchers used tools of epigenomic analysis to trace the specific epigenetic switches controlling each of thousands of genes in both mouse and human retinal cells as the cells progressed through development.

Research Focus: I am involved in the analysis of transcriptomic and epigenomic data in various types of human immune cells and in different diseases.

Dr. Vijayanand also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

The Cancer Genome Atlas Research Network (2013) Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia.

DURECT's epigenomic regulator program includes the lead molecule DUR - 928 in Phase 1 development.

«This is exactly the technology you could use to look for epigenomic changes in specific cell types,» says Martienssen, who is also on the International Human Epigenome Consortium's steering committee.

The crew of researchers involved in the Roadmap Epigenomics Project premiered their findings in more than 20 scientific papers published in February (SN: 3/21/15, p. 6).

The authors next sought to classify lncRNA genes according to genomic and epigenomic context.

A multi-institution research team that includes Children's National Health System attempted to characterize gender - based epigenomic signatures in the human airway early in children's lives with a special attention to defining DNA methylation patterns of the X chromosome.

Host: Dr. Yu Tian Wang Speaker: Dr. Li - Huei Tsai, MIT Title: Alzheimer's disease: from epigenomic networks to circuit mapping

Dr. Vijayanand's primary project focuses on Epigenomics of DENV and MTB.

The NIH Roadmap Epigenomics Consortium has just published the largest collection of epigenomes characterized to date: 111 primary human tissues and cells profiled for histone modification patterns, DNA accessibility, DNA methylation, and gene expression.

Currently, enhancers can be identified through chromatin - based assays, such as ChIP - seq, which predict enhancer elements indirectly based on the enhancer's association with specific epigenomic marks, such as transcription factors or molecular tags on DNA - associated histone proteins.

Ecker says researchers still haven't pinned down the significance of, say, having a methylation mark in one position and not another, and what's really needed is more studies that unify genomic and epigenomic information.

«However, there is emerging evidence that epigenomic changes such as DNA methylation and histone modifications, which affect the ways in which genes are transcribed and translated into proteins, are important features of these processes,» he continues.

Ecker discovered that a kind of epigenomic regulation found first in plants are also present in mammalian brain cells.

Residing in large numbers outside the nucleus of every cell, mitochondria contain their own DNA, with unique features that «may require a reassessment of some of our core assumptions about human genetics and evolutionary theory,» concludes Wallace, director of the Center for Mitochondrial and Epigenomic Medicine at The Children's Hospital of Philadelphia.

Using computational and epigenomic methods, the team found that TCF - 1 behaved in a similar manner on the chromatin of individual T cells.

He uses genome - wide and epigenomic approaches along with bioinformatics and data integration.

METHODS: We examined epigenomic data, allelic activity, motif conservation, regulator expression, and gene coexpression patterns, with the aim of dissecting the regulatory circuitry and mechanistic basis of the association between the FTO region and obesity.

Vijay also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

John Greally, faculty scholar for epigenomics At Albert Einstein College of Medicine tweeted:

Low - input and multiplexed microfluidic assay reveals epigenomic variation across cerebellum and prefrontal cortex

One of my favorite papers from this year was the landmark publication of the NIH Epigenomics Roadmap Consortium, which profiled 111 primary human tissues and cell types for histone modification patterns, DNA accessibility, DNA methylation, and gene expression.

A Berlin - based company called Epigenomics, in partnership with Roche Pharmaceuticals, expects to bring an epigenetic screening test for colon cancer to market by 2008.

Dr. Meissner received the GeneExpression Systems Epigenomics Young Innovator Award in 2009, and has frequently published his work in top international journals.

He is now an associate professor at Weill and director of its WorldQuant Initiative for Quantitative Prediction, as well as leader of the U.S. Food and Drug Administration's SEQC2 Epigenomics Quality Control Working Group.

Epigenomics offers insights into the complex, multilayered system of genome regulation.

This may provide clues to treating the disease by using drugs that influence epigenomic function.»

This exciting new work has been published in the journal Epigenomics.

But Epigenomics plans to set up a proprietary database on differences between healthy and diseased tissues to flag, for example, patterns associated with tumors.

This discovery, published in Nature Communications, opens up a double scenario, one focused on basic epigenomic research and the other biomedical, because of the link between dDsk2 and neurodegenerative diseases.

The new epigenomic data will also enable scientists to search for epigenetic abnormalities underlying adult retinal disease, Dyer said.

The overall goal of the TGen study was to look at genomic and epigenomic events to understand the causes of breast cancer brain metastatic lesions, and identify potential new therapeutic targets.

A microfluidic technology was developed and used to probe epigenomic differences between prefrontal cortex and cerebellum.

Next, the authors turned to their other epigenomic profiling datasets — DNA accessibility (DNAse - Seq), methlation (bisulfite sequencing), and RNA transcription (RNA - Seq) to examine and compare the properties of these chromatin states.

Moreover, the regional susceptibility and tolerance to a particular mutation type is a mixture of various genomic and epigenomic features and selective pressures [64].

To accomplish this, her team will perform epigenomic profiling studies with stored biosamples from patients with type 1 diabetes who are also experiencing metabolic memory.

Reference Marks et al., The Transcriptional and Epigenomic Foundations of Ground State Pluripotency, Cell (2012), doi: 10.1016 / j.cell.2012.03.026 Read a review of this paper: Guenther MG and Young RA (2012).

We're walking into terra incognita by targeting epigenomic elements, like enhancers.

Omics techniques employed in our group range from whole genome sequencing and epigenomic techniques, to single cell / single strand DNA sequencing (Strand - seq; see Figure 1), the latter of which enables haplotype - resolved studies of genetic variation and genome instability.