But there could easily be hundreds
of epilepsy genes, he says, many of which may not be affecting potassium channels.
If this is true, it will be more efficient to identify genes in specific dog breeds first and this may eventually help
identify epilepsy genes in humans.
«We've found the first
dog epilepsy gene and may have explained part of the reason for the high numbers of epilepsy in dogs,» he said.
Meisler MH, Ottman KJ, and Escayg A. Identification of
epilepsy genes in human and mouse.
AFFECTED: The dog carries two mutant copies of
the epilepsy gene and will likely develop the disease in early puppyhood.
CARRIER: The dog carries one mutant and one normal copy of
the epilepsy gene.
The mode of inheritance has been determined to possibly be, autosomal recessive in Keeshonds16, polygenic with one gene of major influence in Belgian Tervurens17, and polygenic recessive in Golden Retrievers.18 Once the mode of inheritance is determined within a breed, we will determine the best technique to try and find a genetic marker linked to
epilepsy gene (s) in each breed.
The exact time frame will depend on the speed of progress in getting a more detailed canine genetic map, and to some extent «luck», whether we happen to randomly pick a marker close to
the epilepsy gene to test, sooner or later.