«We're beginning to unlock some of the mysteries underlying both the acquisition of a memory in the normal brain, as well as how a normal brain is transformed into
an epileptic brain,» said the study's co-senior investigator James McNamara, M.D., a professor in the departments of neurobiology and neurology at Duke University.
The biomarker could also be used to localize
epileptic brain regions for therapeutic removal without the need for additional surgery.
Researchers have identified a unique metabolic signature associated with
epileptic brain tissue that causes seizures.
Current collaborative studies between UIC and Wayne State are working to fully translate this metabolomic signature into a truly non-invasive clinical method to detect and localize
epileptic brain regions with high fidelity using MRI machines.
«Previous studies have used magnetic resonance spectroscopy to look at single metabolites in
epileptic brain tissue, but ours is the first to use high strength magnets to look at multiple metabolites simultaneously,» Loeb said.
«New analysis of brain network activity offers unique insight into epileptic seizures: Researchers are exploring «evolving
epileptic brain networks» to gain a better understanding of brain activity in epilepsy patients and the roles played by different regions of the brain.»
«Statistics method shows networks differ in
epileptic brains: Scientists develop novel method to study brain connections in epilepsy.»
It showed
epileptic brains engage other parts of the brain to handle alertness tasks.
«The ketogenic diet is thought to work by changing the way cells produce energy, and for reasons that are not fully understood, this shift in energy production calms the excitability within
epileptic brains,» says Rho, professor and a member of ACHRI and the HBI.
Not exact matches
«This may point to a greater plasticity in the
epileptic tissue, which to some extent can be compared to the
brain tissue of a newborn,» continues Milos Pekny.
After an extensive investigation aiming at the precise localization of the
epileptic focus,
brain tissue that is damaged due to malformation, injury or other cause, is surgically removed.
Out - of - body experiences normally occur when
brain function is disturbed, such as after an
epileptic seizure, but it is possible to reproduce the experience in healthy people
«It has also been known for a long time that following transient severe
brain injury and prior to an initial spontaneous
epileptic seizure, the concentration of free zinc ions increases in the hippocampus.
His Cambridge, Mass., company MC10 is developing sensors that can fit the contours of the
brain or heart to monitor for early signs of
epileptic seizures or heart arrhythmias.
The Utah team miniaturized electrocorticography electrodes — sensors developed in the 1960s to locate the seizure - causing areas in the
brains of
epileptics — and encased them in thin sheets of silicon.
Patients with epilepsy often have ECoG arrays temporarily implanted in their
brains to determine the location in the
brain of
epileptic seizures, so the scientists were able to study all the data collected from five such patients on healthy, seizure - free nights.
This large - scale
epileptic network comprises various areas of the
brain involved in normal
brain activity during both seizure - free intervals and those involved in so - called pathophysiological activities such as seizures.
«When different
brain regions assume the highest importance within a functional
brain network is the key to improving both prediction and control of
epileptic seizures,» Lehnertz said.
For instance, magnetoencephalography (MEG) is a neuroimaging technique used to map
brain activity and trace pathological abnormalities, such as
epileptic tissue.
Fried led an international team in studying 12 UCLA
epileptic patients who had electrodes implanted in their
brains in order to pinpoint the origin of their seizures prior to surgery.
During certain types of
brain surgery, neural tissue must be removed, either because it is tumorous or because it gives rise to
epileptic seizures.
For example, neural excitation is thought to induce form constants, the dynamic patterns I saw when I closed my eyes under the influence of peyote; these are also generated by migraines,
epileptic seizures, and other
brain disorders.
Traumatic
brain injury accounts for 20 percent of
epileptic seizures, but how or why recurring seizures develop after a severe
brain injury has thus far been unclear.
Then a frustrated group of epilepsy physicians invited computer nerds around the world to take a shot instead, providing data sets recorded from the
brains of human epilepsy patients and
epileptic dogs.
«Imaging scan records
brain activity during
epileptic a.» ScienceDaily.
The excessive burst of new
brain cells after a traumatic head injury that scientists have traditionally believed helped in recovery could instead lead to
epileptic seizures and long - term cognitive decline, according to a new Rutgers New Jersey Medical School study.
UT Southwestern Medical Center researchers have found that halting production of new neurons in the
brain following traumatic
brain injury can help reduce resulting
epileptic seizures, cognitive decline, and impaired memory.
Epileptic seizures can erupt when neurons fire excessively in a sudden burst of energy in the
brain.
Sometimes
brain scans fail to identify which regions need to be removed to stop
epileptic seizures.
Both explore the unique access to the
brain afforded by patients whose
epileptic seizures have proved resistant to drugs.
The instrument would be implanted in the
brain of an
epileptic and detect patterns of electrical discharge.
Current non-invasive techniques can't detect
epileptic areas of the
brain smaller than approximately eight to 10 square centimeters, so many early - stage epilepsy patients often go undiagnosed and untreated.
Loeb and colleagues used a technique called magnetic resonance spectroscopy to identify the metabolomic signature of
epileptic versus non-
epileptic brain tissues removed from nine patients who underwent invasive electrical
brain monitoring as part of their epilepsy surgery.
Surgery to remove areas of the
brain associated with
epileptic activity can help prevent seizures in these patients.
Network activity in the
brain was also normalized, providing additional support for the remarkable ability of tau reduction to suppress
epileptic activity.
Moran Cerf at the California Institute of Technology, Pasadena, and colleagues recruited 12 volunteers who had electrodes implanted in their
brains to record
epileptic seizures.
Professor Patrik Verstreken (VIB - KU Leuven): «Our work shows that increasing specific
brain fats at the synapses of patients with a TBC1D24 mutation is a possible strategy for preventing
epileptic seizures.
They're also investigating how TrkB and phospholipase Cγ1 transform a
brain from normal to
epileptic.
Increasing the concentration of specific fats in the
brain could suppress
epileptic seizures.
«An important goal of this field has been to identify the molecular mechanism by which status epilepticus transforms a
brain from normal to
epileptic,» said McNamara.
As with many other
epileptic syndromes, LKS children often resume normal
brain activity around age 15, when the
brain cells are reaching toward maturation, perhaps spurred by hormonal change.
Their subjects were
epileptics who had electrodes temporarily inserted into their
brains to provide information that could guide surgical treatment.
It is characterized by an inflammation of the
brain, which can result in neurological and psychiatric symptoms, including psychoses,
epileptic seizures and movement disorders.
Since then more than 100 of his
epileptic patients with electrodes implanted in their
brains for diagnostic purposes have volunteered as subjects for basic research.
But it wasn't until May this year that researchers measured the firing of mirror neurons in humans directly, using electrodes implanted in the
brains of
epileptic patients awaiting surgery (Current Biology, vol 20, p 750).
After all,
epileptic bursts of electricity in the
brain alone can trigger everything from desire to ecstasy.
Electrodes implanted deep in the
brains of
epileptic patients have detected single neurons dedicated to the recognition of a particular person in different situations and guises.
He used these to simulate what happens in different parts of the
brain, during
epileptic seizure.
The research for the study was conducted on 19
epileptic patients at the UCLA Medical Center, who required invasive monitoring of
brain activity prior to potential surgical excision of seizure - causing areas of the
brain.
To investigate this connection, Freiburg neurobiologist Prof. Dr. Carola Haas and her team compared gene expression in malformed
brain tissue with that in
epileptic, non-malformed tissue.