The reason behind the abnormal metabolic profile in
epileptic tissue remains unknown and needs to be studied further, said Loeb.
For instance, magnetoencephalography (MEG) is a neuroimaging technique used to map brain activity and trace pathological abnormalities, such as
epileptic tissue.
«This may point to a greater plasticity in
the epileptic tissue, which to some extent can be compared to the brain tissue of a newborn,» continues Milos Pekny.
Not exact matches
After an extensive investigation aiming at the precise localization of the
epileptic focus, brain
tissue that is damaged due to malformation, injury or other cause, is surgically removed.
During certain types of brain surgery, neural
tissue must be removed, either because it is tumorous or because it gives rise to
epileptic seizures.
They found that
tissue with high levels of
epileptic electrical activity was low in lactate and had higher levels of creatine, phosphocreatine and choline, suggestive of abnormal metabolism.
«Previous studies have used magnetic resonance spectroscopy to look at single metabolites in
epileptic brain
tissue, but ours is the first to use high strength magnets to look at multiple metabolites simultaneously,» Loeb said.
Loeb and colleagues used a technique called magnetic resonance spectroscopy to identify the metabolomic signature of
epileptic versus non-
epileptic brain
tissues removed from nine patients who underwent invasive electrical brain monitoring as part of their epilepsy surgery.
Researchers have identified a unique metabolic signature associated with
epileptic brain
tissue that causes seizures.
Surgery can be an option for a minority of patients who do not respond to medications or other treatments and have
epileptic scar
tissue that can be removed safely.
To investigate this connection, Freiburg neurobiologist Prof. Dr. Carola Haas and her team compared gene expression in malformed brain
tissue with that in
epileptic, non-malformed
tissue.