Sentences with word «epistasis»

Better understanding of these factors is a major area of interest in the lab, with some of the specific projects including tissue - specificity of cis - regulatory variants in the GTEx data set, immune response eQTLs where genetic variants contribute to inter-individual response to immunological stimuli, and haplotypic epistasis between regulatory and coding variants.
Detection of Epistasis for Flowering Time Using Bayesian Multilocus Estimation in a Barley MAGIC Population
The search for epistasis by Andrew Brown Figuring out the role of each gene is a complex task.
Rather, he says, the most likely explanation is a phenomenon known as epistasis, where genes can interact so as to greatly multiply an effect.
Epistasis makes fitness trajectories unpredictable in yeast, even as they converge upon the same biological pathway.
In our model, disease arises due to a global epistasis among mutations which act additively on the liability scale (i.e. a liability threshold model).
Unequal duplicate epistasis - the normal allele at clf1 is a dominant suppressor of the recessive phenotype at clf2, and the normal allele at clf2 is a semidominant suppressor of the recessive phenotype at the clf1 locus.
226/4: 00 Are genetic interactions influencing gene expression in humans evidence for biological epistasis or statistical artifacts?
Epistasis between COMT and MTHFR in Maternal - Fetal Dyads Increases Risk for Preeclampsia.
Such interactions, when the effect of a mutation is dependent on another, are known as epistasis.
This turning off or hiding the expression of another gene is called epistasis.
Genetic screens, epistasis analyses and site - directed mutageneses with the main CWI sensors (Wsc1, Wsc2 and Mid2) and the cytokinesis regulator Inn1 will be used to identify new components involved in the regulatory networks in vivo.
Schizophrenia researcher Daniel Weinberger of the National Institute of Mental Health in Bethesda agrees that the paper adds to evidence that epistasis — which has been shown in model organisms such as yeast but difficult to prove in humans — is «robust and ubiquitous.»
This technology can be used to study a variety of topics, from nutrient acquisition and responses to immune pressures to epistasis and genetic interactions.
Epistasis and the Evolutionary Process.
The striking differences observed in Themis1 - deficient rats of the BN and LEW genetic backgrounds suggest that an epistasis between Themis1 and other gene (s) controls Treg function.
In contrast with the BN rat strain, the disruption of the Themis1 gene in LEW rats does not lead to the spontaneous development of IBD or functional Treg defect, suggesting that an epistasis phenomenon in the BN genetic background controls these phenotypes.
Sex linkage, autosomal genes and epistasis 6.
Epistatic effects are at their most dramatic in mixed breed dogs where, unlike a purebred dog, we have a relatively spotty (pun intended; coat color and patterning is a great example of epistasis) understanding of how the sequences from lots of contributing breeds will interact.
There is also a pesky genetic phenomenon known as epistasis.
Association results have generally been marked by at least some degree of inconsistency, for which a number of explanations such as underpowered samples, small effect size, epistasis, polygenic contributions and population stratification have been suggested.
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