Not exact matches
The new research finds that the stiffness of the extracellular matrix and the availability of certain ligands (molecules that bind to cell membranes) can together determine which genes are actually
called on — and whether normal
epithelial cells begin to exhibit the behaviors characteristic of highly malignant
cancer cells.
HER2 - positive breast
cancer, which is associated with poor prognosis, has been traced to an excess of signaling through receptors, or docking ports,
called HER2 found on the surface of certain mammary
epithelial cells.
«We found that women who consume foods high in two sub-groups of powerful substances
called flavonoids — flavonols and flavanones — had a significantly lower risk of developing
epithelial ovarian
cancer.
Weaver also said that the predictions made by jamming models resemble what biologists
call extrusion, a process by which dead
epithelial cells are squeezed out of crowded tissue — the disfunction of which has recently been implicated in certain types of
cancer.
A class of drugs
called EZH2 inhibitors are currently in clinical development for both hematological malignancies and solid tumors and may be effectively targeted to
epithelial ovarian
cancers overexpressing the CARM1 protein.
Cancer cells acquire the ability to invade and migrate, or metastasize, to other tissues, through a process
called Epithelial - Mesenchymal Transition (EMT).