The researchers knew they faced a major challenge: sorting and separating «sticky»
epithelial cell progenitors without destroying them.
Further tests suggested that
epithelial cell progenitors helped by restoring the connection between cells called myoepithelial contractile cells and the lacrimal gland's secretory cells, which produce tears.
Not exact matches
Transient Silencing of 14 -3-3sigma promotes proliferation of p63 - positive
progenitor cells isolated from human breastmilk in mammary
epithelial cell culture.
In this study, the researchers used
progenitor cells that were poised to become
epithelial tissue, a key component of the lacrimal gland.
Once the bacterial
cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of
progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric
epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.
Jennifer Fish (Huttner, MPG)-- «The evolution of neuronal
progenitor cell division in mammals: the role of the abnormal spindle - like microcephaly associated (Aspm) protein and
epithelial cell polarity» (2007)
Subsequent single -
cell flow cytometric assays linked this shorter G1 phase to the more rapid loading of minichromosome maintenance (MCM) helicase complexes when compared to differentiated
cells with longer G1 phases (neural
progenitor cells and retinal pigmented
epithelial cells).
We have recently shown that in avian embryos, muscle formation is initiated by Delta1 - positive neural crest
cells migrating from the dorsal neural tube that, in passing, trigger NOTCH signalling and myogenesis in selected
epithelial somite
progenitor cells, allowing them to migrate into the nascent muscle to differentiate.
Initial reprogramming efforts used adult mouse limbal
progenitors (
epithelial cells which express Sox2, Klf4, and Myc) which the group reprogrammed to iPSCs using embryonic stem
cell CM (ESCM) supplemented with MAPK and GSK3 inhibitors as previously described [4, 5].
The researchers conclude that this could be owing to the bone marrow - derived MSCs being able to act as
progenitor cells, similar to alveolar
epithelial type II
cells.
In chick embryos, skeletal muscle formation is initiated by migrating Delta1 - expressing neural crest
cells that trigger NOTCH signaling and myogenesis in selected
epithelial somite
progenitor cells, which rapidly translocate into the nascent muscle to differentiate.
Considering that miR - 142 is highly expressed in human BCSCs, but weakly expressed or undetectable in the stem /
progenitor population of the mammary
epithelial cells, our result suggest that the upregulation of miR - 142 and its enhancement of the miR - 150 expression seem to be especially relevant in the breast tumor progression in vivo.