Sentences with phrase «epithelial cell proteins»

Using a crystal structure of a complex protein compound of botulinum neurotoxin, Rongsheng Jin, associate professor of physiology & biophysics at UC Irvine, and collaborators found that these compounds — called clostridial hemagglutinin (HA)-- bind with epithelial cell proteins in the intestines of patients, which initiates a process that disrupts the close intercellular seals so that the complex toxin molecules can slip through the epithelial barrier.

In further tests, he and his colleagues designed a mutated version of the botulism compound, based on the novel crystal structure, in which HA would not bind with the epithelial cell protein E-cadherin.

Not exact matches

Stephen O'Keefe: The chief biomarker we studied was Ki67 epithelial cell [proteins].

He determined that epithelial cells lining the brain's blood vessel walls contain a surface protein, or receptor, that can snag insulin, the hormone essential for metabolizing carbohydrates and fats.

«In our human airway epithelial model system, one of the drugs destabilizes and deactivates the protein that the other drug tries to correct,» said Martina Gentzsch, PhD, an assistant professor of cell biology and physiology and senior author of the UNC Science Translational Medicine paper.

In those cells the Esrp1 and Esrp2 proteins enforce epithelial - specific splicing isoforms for hundreds of different genes, as Carstens and his team have shown in studies since 2009.

Using animal models, Pickles has already found candidate molecular biomarkers that indicate if the epithelial cells in the tiniest airways are expressing the RSV NS2 protein.

According to this study, it's this NS2 protein and its effect on epithelial - cell shedding that makes RSV by far the most common cause of bronchiolitis in otherwise healthy young children.

«But what we've now shown is that RSV has an increased ability to cause airway obstruction because, during an RSV infection, the virus expresses a specific RSV - encoded non-structural protein, or NS2, in epithelial cells, causing the cells to shed from the airway lining and into the airway lumen.

They found that the protein seems to help maintain several traits in normal breast cells, including the ability to adhere to other epithelial cells, and the presence of molecules marking the cells as differentiated and not capable of self - renewal like breast stem cells.

«It was known that the epithelial cells which line the airways in the lungs produce a protein called thymic stromal lymphopoietin (TSLP) that causes inflammation.

«In the initial phase, epithelial cells act as non-professional phagocytes to clear up milk protein and milk fat globules.

The third, SFTPA2, affects a protein expressed only in the fluid that bathes the lung's epithelial cells.

In the study, the protein Miro1 was shown to regulate the transfer of mitochondria from mesenchymal stem cells to epithelial cells.

According to Dr. Bleich and his co-investigators, «Epithelial barrier function is predominantly dependent on tight junction proteins, which regulate transport into and between cells.

«The inflammasome in turn activates the enzyme caspase - 1, which then produces two proteins (IL - 1β and IL - 18) that play important roles in the GI tract, including activation of immune cells, induction of antimicrobial peptides, and regulation of epithelial cell proliferation.»

Physical separation of the two proteins is an «easy - to - conceptualize mechanism by which airway epithelial cells are poised to heal themselves the moment they are injured.»

Because airway epithelial cells are tightly connected, the researchers posited that the membrane proteins on opposite sides don't normally mix.

After lung epithelial cells are damaged, a molecule called heregulin binds to another protein, erbB2.

The cells I had were ovine mammary epithelial cells: we were looking to increase expression of proteins in milk.

We are studying these proteins in the intestine and liver in vivo, as well as in epithelial cell lines.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

Among the proteins known to be important in the regulation of copper levels in epithelial cells are two Cu (I)- transporting membrane ATPases, ATP7A (Menkes protein) and ATP7B (Wilson protein).

Using colorfully labeled antibodies to light up the new protein under their microscopes, they found that it was present where Listeria entered cells and also present at adherens junctions between epithelial cells.

Results: Researchers at Pacific Northwest National Laboratory have identified the secretome — defined as the family of proteins secreted by cells — of human mammary epithelial cells, or HMEC.

Jennifer Fish (Huttner, MPG)-- «The evolution of neuronal progenitor cell division in mammals: the role of the abnormal spindle - like microcephaly associated (Aspm) protein and epithelial cell polarity» (2007)

«The new protein plays a key role in the formation of adherens junctions of epithelial cells, and Listeria uses it for its own infectious process.»

ARHGAP21 Protein, a New Partner of α - Tubulin Involved in Cell - Cell Adhesion Formation and Essential for Epithelial - Mesenchymal Transition.

Inside the epithelial cell, the tail of E-cadherin binds to a protein called α - catenin, which recruits other proteins that spur assembly and disassembly of actin filaments and is absolutely critical for strong adherence between epithelial cells.

Biological Function of Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer Jimin Shi, Lingyun Zhang, Daibing Zhou, Jinguo Zhang, Qunbo Lin, Wencai Guan, Jihong Zhang, Weimin Ren, Guoxiong Xu J. Cancer 2018; 9 (4): 745 - 756.

Laminin - 111 is important during early epithelial development and differentiation of the epiblast, and is commonly used as a general attachment protein in cell culture.

The membrane is coated with proteins that support 3 - D cell growth and it's seeded with human intestinal epithelial cells (from a cell line originally isolated from a colon cancer).

L - Threonine induces heat shock protein expression and decreases apoptosis in heat - stressed intestinal epithelial cells.

Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells.

Furthermore, there was a negative expression for Cyclin D1 protein in normal ductal epithelial cells, while the benign group revealed week positivity immunostaining Cyclin D1 in 60 %, whereas, the malignant group represented a variable positivity of immunostaining scores; they were classified as 3 (10 %) cases were weak, 9 (30 %) moderate cases and 12 (40 %) strong expression cases.

Chromosome - associated protein D3 promotes bacterial clearance in human intestinal epithelial cells by repressing expression of amino acid transporters.

Dorsal closure involves three entities: the cells that fill the gap, called amnioserosa cells, a cable of the protein actin which runs around the gap, and the epithelial cells that eventually stretch over and seal the gap.Until now, scientists believed dorsal closure started when some unknown signal made the amnioserosa cells and the actin cable contract.

MUC1 is protein found on epithelial cells, such as those that line the intestine, that is overexpressed in many cancers, including colorectal and breast cancers.

Prominin - 2 is a cholesterol - binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into urine.

Uromodulin (or Tamm - Horsfall protein) is the most abundant protein in normal urine, specifically produced in the kidney by epithelial cells of the thick ascending limb (TAL) of Henle's loop.

Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels

Yet in 1996 researchers found that women consuming soy protein isolate had an increased incidence of epithelial hyperplasia, a condition that presages malignancies.45 A year later, dietary genistein was found to stimulate breast cells to enter the cell cycle, a discovery that led the study authors to conclude that women should not consume soy products to prevent breast cancer.46

«Effect of whey protein isolate on intracellular glutathione and oxidant - induced cell death in human prostate epithelial cells.»

Intestinal permeability was assessed by Ussing chamber; epithelial cell (EC) ultra-structure by electron microscopy; RNA expression of genes coding for junctional proteins by Q - real - time PCR; immune response by in - vitro antigen - specific T - cell proliferation and cytokine analysis by cytometric bead array; intestinal microbiota by fluorescence in situ hybridization and analysis of systemic antibodies against intestinal microbiota by surface staining of live bacteria with serum followed by FACS analysis.

Another similar study demonstrated a 29.2 % increased number of breast epithelial cells in 7 of 24 women when they took soy protein supplements.

A lectin is another defensive plant weapon — it's a sticky protein that binds to epithelial cells in your small intestine, thus triggering an inflammatory response to remove it.

The group who consumed soy protein had significant increases in the proliferation of epithelial cells in the breasts.

In the small intestine, gluten triggers the release of zonulin, a protein that regulates the tight junctions between epithelial cells and therefore intestinal, but also blood - brain barrier function.

The most common cause of obstruction is a urethral plug, which consists of mineral crystals (e.g., struvite, calcium oxalate), white blood cells, red blood cells, protein (mucus), and epithelial cells.5 The underlying cause of urethral plugs is unknown; however, plugs have been linked to struvite crystalluria — suggesting that diet may play a role — and idiopathic cystitis.6 Other causes of urethral obstruction include urethral edema and spasm associated with lower urinary tract inflammation and pain.7 Uroliths, neoplasms, and urethral strictures can also lead to urethral obstruction; however, they are reported less frequently than other causes.5

Dog's urine normally contains a trace amount of protein in the urine, as proteins are blocked by the glomerulus, the part of the kidney that filters waste products, or pass through the glomerulus and then reabsorbed by renal tubes or broken down by the epithelial cells of the renal tubes.