Sentences with phrase «epithelial cells by»

Green tea polyphenols inhibit the sodium - dependent glucose transporter of intestinal epithelial cells by a competitive mechanism

We developed a way of getting siRNAs into epithelial cells by either mixing them with a transfection lipid used to introduce exogenous nucleic acids into cells in the lab or by adding a cholesterol tag to the end of the RNA sequence that allowed the RNA to be taken up into cells.

Chromosome - associated protein D3 promotes bacterial clearance in human intestinal epithelial cells by repressing expression of amino acid transporters.

Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism.

Regulation of purinergic signaling in biliary epithelial cells by exocytosis of SLC17A9 - dependent ATP - enriched vesicles.

Uptake of rabies virus into epithelial cells by clathrin - mediated endocytosis depends upon actin.

Anne - Kathrin Classen (Eaton, MPG)-- «Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway» (2006)

Effects of microRNA - 211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice.

miR - 34a suppresses proliferation and induces apoptosis of human lens epithelial cells by targeting E2F3.

MicroRNA -7-5p regulates the proliferation and migration of intestinal epithelial cells by targeting trefoil factor 3 via inhibiting the phosphoinositide 3 - kinase / Akt signalling pathway.

«hPIV gains entry to human respiratory epithelial cells by attaching to carbohydrate receptors.

However, compared to other avian influenza viruses, the attachment to epithelial cells by H7N9 in the bronchioles and alveoli of the lung was more abundant and the viruses attached to a broader range of cell types.

Not exact matches

These growth modulators are produced either by the epithelial cells of the mammary gland or by activated macrophages, lymphocytes (mainly T cells), or neutrophils in the milk.

As lipid droplets exit the mammary epithelial cell, they are enveloped by cell membrane and secreted into milk as membrane - bound globules of fat.

Stage I lactogenesis, or secretory initiation, occurs during pregnancy and is defined by the differentiation of mammary alveolar epithelial cells into specialized secretory cells, termed lactocytes (1).

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

In cell culture, high expression levels of GPR161 induced proliferation of mammary epithelial cells, disrupted the acinar structures formed by these cells, and enhanced their invasive capacity.

The «dry» form is caused by natural deposits on the retina that gradually kill retinal pigment epithelial cells.

The invasion of epithelial cells and immune cells are controlled by two separate gene clusters called Salmonella Pathogenicity Islands 1 and 2 (SPI1, SPI2) respectively.

Because mice lacking both genes would not be born alive, the scientists followed up this lead by making «conditional knockout mice,» in which Esrp1 and Esrp2 activity was normal early in fetal development, but then was switched off in skin epithelial cells.

They found that infection of the narrowest airways of the lung by PIV3 alone caused moderate levels of inflammation, but after infection by PIV3 expressing RSV NS2, the epithelial cells lining the narrow airways were shed rapidly into the airway lumen.

We did notice, though, that the epithelial cells infected by RSV looked very different during infection compared to those infected by PIV3.»

According to this study, it's this NS2 protein and its effect on epithelial - cell shedding that makes RSV by far the most common cause of bronchiolitis in otherwise healthy young children.

But the pH - responsiveness also allows the bacterium to escape a certain death by detaching from epithelial - and mucus cells that are shed into the gastric juice,» says Jeanna Bugaytsova, researcher at Department of Medical Biochemistry and Biophysics and first - author of the article.

Recently published in the journal eLife and featured in a poster session at this year's American Association for Cancer Research (AACR) annual meeting, preclinical experiments show for the first time that PLK1 promotes the migration of prostate cancer cells by setting in motion a process that induces what is known as the epithelial - to - mesenchymal transition (EMT).

«Our system is based around a molecule called E-cadherin, which suppresses tumor growth in part by maintaining cells in an epithelial rather than a mesenchymal state,» Tomoki Muramatsu of TMDU says.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

By manipulating it in vitro, a team of researchers led by Prof. David Mooney at Harvard SEAS have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast canceBy manipulating it in vitro, a team of researchers led by Prof. David Mooney at Harvard SEAS have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast canceby Prof. David Mooney at Harvard SEAS have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast canceby which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

Further tests suggested that epithelial cell progenitors helped by restoring the connection between cells called myoepithelial contractile cells and the lacrimal gland's secretory cells, which produce tears.

But by hierarchical clustering of observed alterations in endocytosis, the researchers identified two distinct cancer phenotype clusters, one marked by mutations in the oncogene KRAS in mesenchymal cells and the other by changes in epithelial cells.

«It is striking that these changes, found in many human cancers, can be induced in normal mammary epithelial cells simply by varying the stiffness or composition of the matrix surrounding them.»

These structures were further examined by tissue - level and immunohistochemical tools, revealing ducts with «excessive layers» of epithelial cells, potentially pre-cancerous lesions that were «highly proliferative» compared to normal ducts, they add.

But Raz and colleagues have found that TPRV1 is also expressed by epithelial cells of the intestines, where it is activated by epidermal growth factor receptor or EGFR.

In most cases, infected epithelial cells are quickly killed by CD8 + cells, a type of white blood cells; only occasionally does the infection overwhelm the immune system, resulting in a lesion.

To test their idea for the dry form, Amir Kashani of the University of Southern California in Los Angeles and his colleagues coated 6 by 4 - millimetre slithers of polymer with retinal pigment epithelial cells they had grown, then transplanted these into four people.

It has been designed for treating the «dry» form of macular degeneration, caused by deposits on the retina gradually killing retinal pigment epithelial cells, which support light - capturing cells.

To investigate, a team led by Gerburg Wulf, MD, PhD, a physician scientist in the Hematology / Oncology Division at Beth Israel Deaconess Medical Center (BIDMC) and an Associate Professor of Medicine at Harvard Medical School, cultured breast cells called primary mammary epithelial cells (MECs) in the presence of EBV.

Irritated by the main cholera toxin, the intestine will gush fluid, and a person will develop cramping, vomiting, and, most notoriously, diarrhea that rapidly becomes a staggering volume of «rice - water» stool: a watery liquid filled with mucous flakes and epithelial cells.

The team's findings may also be relevant to inflammatory disorders that affect other parts of the body, such as the linings of the gut and bowel, which, like the skin, are replenished by epithelial stem cells.

The goal of the first experiment was to see whether lncRNAs are differentially expressed in prostate cancer by measuring total RNA from prostate cancer cell lines and normal epithelial prostatic cells using NCode human ncRNA array and SurePrint G3 human lncRNA microarrays.

Researchers have built a model to investigate the metastasis of cancer by examining the metabolism of breast epithelial cells and look at the role of signaling.

A team of researchers led by Professor Lindsay Hinck at the University of California, Santa Cruz, examined the ROBO signaling pathway in breast epithelial cells and found that one family member, ROBO1, enhances cellular contractility and stimulates assembly of cell - matrix adhesions.

It consisted in exposing human umbilical cord epithelial cells to the substances produced by the nerve cells of the previous experiment.

Physical separation of the two proteins is an «easy - to - conceptualize mechanism by which airway epithelial cells are poised to heal themselves the moment they are injured.»

The effects of consuming emulsifiers were eliminated in mice devoid of microbiota (germ - free mice), and transplanting microbiota from emulsifier - treated mice to germ - free mice was sufficient to transfer alterations in intestinal epithelial cells» homeostasis, suggesting a central role played by the microbiota in tumor development.

When a bacterium with the correct - shaped key — called an adhesin — comes by, it attaches itself to the corresponding epithelial cell.

Rather, he was intrigued by its documented ability to dampen the immune responses triggered by vaginal epithelial cells when exposed to toxins.

In Nrk mutant mice, therefore, mammary tumorigenesis was proposed to be triggered by a combination of dysregulation of proliferation in mammary epithelial cells and excessive blood estrogen.

Interestingly, CD44 + / CD24 − population can be generated by induction of epithelial — mesenchymal transition (EMT) by treating breast epithelial cells with EMT - inducing agents such as TGF - β1 (6).

Starting with procedures other research teams had previously worked out to convert iPSCs into keratinocytes, Xu's team demonstrated that by carefully controlling the timing of the growth factors the cells received, they could force the iPSCs to generate large numbers of epithelial stem cells.