«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal
epithelial cells and the
immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional
in vitro and animal models of bacterial overgrowth and inflammation of the intestines.
In most cases, infected epithelial cells are quickly killed by CD8 + cells, a type of white blood cells; only occasionally does the infection overwhelm the immune system, resulting in a lesio
In most cases, infected
epithelial cells are quickly killed by CD8 +
cells, a type of white blood
cells; only occasionally does the infection overwhelm the
immune system, resulting
in a lesio
in a lesion.
Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the
immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors)
in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals,
epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast
cells as effector
cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast
cells, the allergic effector unit, mast
cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast
cell activation
in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels
While vitamin A is best known for its vital role
in vision, the retinoid forms of this vitamin also participate
in physiological activities related to the
immune system, inflammatory
system, maintenance of
epithelial and mucosal tissues, growth, reproduction, bone development, creation of red blood
cells, and production of spermatozoa (male reproductive
cells).