The phrase
"epithelial layer" refers to a thin sheet of cells that covers the surfaces of our body, such as the skin, lining of organs, and inner parts of blood vessels. It acts as a protective barrier, acting as a shield against harmful substances and infections while also allowing necessary substances and fluids to pass through.
Full definition
The team created microscopic wounds in the pupae's
epithelial layer using a laser that can be focused down to a point small enough to punch microscopic holes in individual cells (less than a millionth of a meter).
Remarkably, even though this lab - made toxin compound contains the fully active live toxin molecule, it was not orally toxic when tested on mice because the mutated HA can not break up the intercellular seals and, therefore, the toxin compound can not be absorbed through
the epithelial layer.
Further analyses suggested that the presence of Cd14 becomes even more important when
the epithelial layer is disturbed rather than during steady - state conditions,» commented Dr. Bleich.
It was through the analysis of these high - resolution images that the team made the important observation that loss of Alix leads to an increased number of cells caught in the act of being discharged from
the epithelial layer.
«It is an important physiological mechanism for the ordered removal of cells from
the epithelial layer, but when it is out of control has profoundly damaging effects,» said Campos.
When they mimicked physical damage to
the epithelial layer, heregulin made its way to the other sides, activated erbB2, and stimulated cell growth.
In a mouse model of skin wound healing (regeneration), we demonstrated the unique expression of β3 - integrin in PHD2 - deficient keratinocytes, which improved healing through the enhanced migration of
the epithelial layers (Kalucka et al., Mol.
One of the primary tools used to measure the health of these membranes is transepithelial electrical resistance (TEER), an ohmmeter with microscopic filament attachments that allows you to measure both the inside and outside of the membrane, giving you an indication of the resistance across
the epithelial layer.