Sentences with phrase «epithelial ovarian cancer»
Bioengineered 3D platform to explore cell - ECM interactions and drug resistance of epithelial ovarian cancer cells.
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Sulforaphane induces cell cycle arrest by protecting RB - E2F - 1 complex in epithelial ovarian cancer cells.
The researchers exposed patient - derived epithelial ovarian cancer cells growing in their laboratory to a specific NSAID, indomethacin, and confirmed the DrugPredict finding.
In the new study, DrugPredict suggested non-steroidal anti-inflammatory drugs, also known as NSAIDs, could have applications for epithelial ovarian cancer.
The new method detected cancer in 86 % of women with invasive epithelial ovarian cancer (iEOC), whereas the conventional test used in previous trials or in clinical practice would have identified fewer than half of these women (41 % or 48 % respectively).
Therefore, new treatment modalities and paradigms are needed in order to significantly improve the prognosis of women diagnosed with epithelial ovarian cancer.
«We found that women who consume foods high in two sub-groups of powerful substances called flavonoids — flavonols and flavanones — had a significantly lower risk of developing epithelial ovarian cancer.
The LION trial randomized 650 patients with advanced epithelial ovarian cancer and macroscopic complete resection to either systematic pelvic and para-aortic LNE (323 patients in intention - to - treat cohort), or no LNE (324 patients in intention - to - treat cohort).
They also found differences in the types of bacteria in the upper reproductive tracts of women with and without epithelial ovarian cancer.
The program could help identify safe alternatives for diseases — like epithelial ovarian cancer — that desperately require new treatment options.
In the Oncogene study, DrugPredict produced a prioritized list of 6,996 chemicals with potential to treat epithelial ovarian cancer.
Biological Function of Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer Jimin Shi, Lingyun Zhang, Daibing Zhou, Jinguo Zhang, Qunbo Lin, Wencai Guan, Jihong Zhang, Weimin Ren, Guoxiong Xu J. Cancer 2018; 9 (4): 745 - 756.
A class of drugs called EZH2 inhibitors are currently in clinical development for both hematological malignancies and solid tumors and may be effectively targeted to epithelial ovarian cancers overexpressing the CARM1 protein.
Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf G, English J, Kirschmeier PT, Velculescu VE, Paweletz CP, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R.: Establishment of patient - derived tumor xenograft models of epithelial ovarian cancer for pre-clinical evaluation of novel therapeutics.
The findings could represent the first step toward a new therapy regimen for epithelial ovarian cancer.
[1] Zhang L, Conejo - Garcia JR, Katsaros D, Gimotty PA, Massobrio M, Regnani G, Makrigiannakis A, Gray H, Schlienger K, Liebman MN, Rubin SC, Coukos G. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
The research reveals that women who consume foods containing flavonols and flavanones (both subclasses of dietary flavonoids) significantly decrease their risk of developing epithelial ovarian cancer, the fifth - leading cause of cancer death among women.
FORWARD1: A Randomized, Open Label Phase 3 Study to Evaluate the Safety and Efficacy of Mirvetuximab Soravtansine (IMGN853) Versus Investigator's Choice of Chemotherapy in Women with Folate Receptor Alpha - Positive Advanced Epithelial Ovarian Cancer, Primary Peritoneal Cancer or Fallopian Tube Cancer
The sixteen chapters of Advances in Ovarian Cancer Management present a concise, timely and comprehensive overview on the current status of the etiology, diagnosis and treatment of women with epithelial ovarian cancer.
Gwinn, M. et al Pregnancy, breast feeding, and oral contraceptives and the risk of epithelial ovarian cancer.
Lactation and the risk of epithelial ovarian cancer.
Background: Epidemiologic studies have yielded inconsistent findings between breastfeeding and epithelial ovarian cancer (EOC) risk.
This discovery is a result of research on the effects of ONA on a preclinical model of epithelial ovarian cancer (EOC) both in vivo and in vitro.
To capture uncommon genetic variants, the study used an exome genotyping array to genotype 7,060 epithelial ovarian cancer (EOC) cases and 6,712 cancer - free women from the Ovarian Cancer Association Consortium.
A total of 640 women in the MMS group had surgery for suspected cancer, of whom 133 women had invasive epithelial ovarian cancers (iEOC).
She said: «This is the first large - scale study looking into whether habitual intake of different flavonoids can reduce the risk of epithelial ovarian cancer.
«Potential for personalized immunotherapy to large variety of cancers: New methods developed for the study could be applied to devise personalized, cell - based immunotherapies for epithelial ovarian cancer or other types of tumors.»
Approximately 50 % of epithelial ovarian cancers (EOC) exhibit defective DNA repair via homologous recombination (HR) due to genetic and epigenetic alterations of HR pathway genes.
Nine out of 10 ovarian cancers are epithelial ovarian cancers — deriving from the outer (epithelial) layer of the ovary.
Large - scale genomic studies have shown that half of epithelial ovarian cancers (EOCs) have alterations in genes regulating homologous recombination (HR) repair.
Metastasis of epithelial ovarian cancer (EOC) is regulated by the SDF - 1 / CXCR4 axis.
In collaboration with the Institut Curie hospital, we are currently investigating origin and consequences of centrosome abnormalities in epithelial ovarian cancers (EOC).
Rojas V, Hirshfield KM, Ganesan S, Rodriguez - Rodriguez L. Molecular Characterization of Epithelial Ovarian Cancer: Implications for Diagnosis and Treatment.
b. Epigenetic approaches to chemotherapy resistance and cancer stemness in epithelial ovarian cancer.
Zhang is committed to finding a cure for epithelial ovarian cancer, the most lethal gynecological malignancy in the developed world.
a. Mechanism - guided therapeutic strategies for genetic alterations that affect the SWI / SNF chromatin remodeling complex in epithelial ovarian cancer (such as ARID1A mutation in clear cell and endometrioid subtypes of ovarian cancer, and CARM1 amplification / overexpression in high - grade serous ovarian cancer).
c. Epigenetic approaches to primer for and / or synergize with immunological therapy in epithelial ovarian cancer.
In particular, the lab investigates how alterations in epigenetics — or the heritable changes that affects gene expression without alterations in the underlying DNA sequence — contribute to epithelial ovarian cancer.
NY - ESO - 1 is one of the few tumor antigens that have restricted expression in normal tissue but become aberrantly expressed in epithelial ovarian cancers and other solid tumors.
Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer
A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer.
Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study, International Journal of Epidemiology, published online.
Dietary fat intake and risk of epithelial ovarian cancer.