Sentences with phrase «epithelial stem cells in»
Interestingly, we detected upregulation of p16 and p15 in Polycomb - null skin epithelial stem cells in young mice where it is normally detected only in aged animals.
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Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.
Three years after publishing a groundbreaking paper in which she isolated adult retinal pigment epithelial stem cells, Temple is in preclinical trials with rats.
Digging deeper, the researchers found the inflammatory response through IL - 1β production was initiated in Paneth cells, which are known to protect the intestinal stem cells to replenish the epithelial lining.
They found that the protein seems to help maintain several traits in normal breast cells, including the ability to adhere to other epithelial cells, and the presence of molecules marking the cells as differentiated and not capable of self - renewal like breast stem cells.
In the study, the protein Miro1 was shown to regulate the transfer of mitochondria from mesenchymal stem cells to epithelial cells.
These differently expressed microRNAs may contribute to stem cell and epithelial (tissue cells) abnormalities in diabetic corneas.
The epithelial stem cells, when implanted into immunocompromised mice, regenerated the different cell types of human skin and hair follicles, and even produced structurally recognizable hair shaft, raising the possibility that they may eventually enable hair regeneration in people.
Xiaowei «George» Xu, MD, PhD, associate professor of Pathology and Laboratory Medicine and Dermatology at the Perelman School of Medicine, University of Pennsylvania, and colleagues published in Nature Communications a method for converting adult cells into epithelial stem cells (EpSCs), the first time anyone has achieved this in either humans or mice.
Such a depot or niche of endothelial stem - like cells would be analogous to the epithelial stem cells located in the anterior limbus that supply cells to the basal epithelium as transient amplifying cells, the cells that become committed to the state of terminal differentiation [11,15].
His recent published work describes the rescued visual function in animals using retinal pigment epithelial cells derived from human embryonic stem cells and a method for deriving stem cells using a single - cell approach that does not harm embryos.
Subsequent studies, as reviewed by Daniels et al. [11] and Lavker and Sun [12] showed that some cells located in the anterior limbus are stem cells which partially differentiate into transient amplifying cells while migrating centrally into the posterior epithelial layer of the cornea.
Her group is particularly interested in the cellular and molecular mechanisms which control lung epithelial stem cell fate decisions.
The stem cells in the bulge are multipotent epithelial stem cells, and can become, or differentiate into, all the epithelial cell types in the follicle (including hair follicles, epidermis, and sebaceous glands)(Oshima et al., 2001).
Xeno - Free and Defined Human Embryonic Stem Cell - Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large - Eyed Preclinical Model
In particular, they are focused on studying the functional role and molecular mechanisms of cellular senescence in both of these events, and how a deregulation of normal epithelial stem cell proliferation is involveIn particular, they are focused on studying the functional role and molecular mechanisms of cellular senescence in both of these events, and how a deregulation of normal epithelial stem cell proliferation is involvein both of these events, and how a deregulation of normal epithelial stem cell proliferation is involved.
Limbal epithelial stem cells (LESCs) reside in the basal layer of the limbal area, at the vascularised junction between the corneal and conjunctival epithelium.
Researchers demonstrate that autologous oral mucosal epithelial cells expanded under good manufacturing practice requirements can reverse limbal stem cell deficiency in injured eyes up to 24 months, representing an advance in ocular tissue regeneration and transplantation
Characterization of a naturally occurring breast cancer subset enriched in epithelial - to - mesenchymal transition and stem cell characteristics.
IL - 22 also plays a role in epithelial cell repair and has direct effects on the intestinal stem cells [22 — 24].
8) Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P.J. and Clevers, H. Depletion of epithelial stem - cell compartments in the small intestine of mice lacking Tcf - 4.
1) Notch - 1 induces epithelial — mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells:
Notch - 1 induces Epithelial - mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
Titles: 1) Notch - 1 induces Epithelial - mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
Our final review article, from the labs of Maximilian Boesch (Kantonsspital St. Gallen, Switzerland) and Andreas Seeber (Medical University of Innsbruck, Austria), provides an update on the role of epithelial cell adhesion molecule (EpCAM) in cancer stem cells (CSCs) and the epithelial ‐ to ‐ mesenchymal transition (EMT) in colorectal cancer (CRC).
For example, ΔNp63α is expressed in epithelial stem cells, while TAp63α is expressed in fully differentiated cell types.
The ΔN isoforms of p63 may also serve as stem cell markers in a variety of epithelial cell types, including endometrium [30], cervix [31], breast [32], prostate [33], and in stratified squamous epithelium [21,34].
The Center for Regenerative Medicine (CReM) at Boston University and Boston Medical Center has engineered two new categories of lung epithelial cells in vitro using pluripotent stem cells.
Creating human lung epithelial cells in the lab has been a challenge, and lineage - specific reporters, which indicate each cell's specific type, are key to understanding lung epithelial stem cell development.
Interestingly, long - term — cultured human epithelial cancer cells in clonal cultures also form holoclones, meroclones, and paraclones, and tumor cell holoclones have been hypothesized to harbor stem - like cells or cancer stem cells.
Moreover, these results suggest that intestinal stem cell - intrinsic DNA methylation patterns establish and maintain regional gut specification and are involved in early epithelial development and disease.
Considering that miR - 142 is highly expressed in human BCSCs, but weakly expressed or undetectable in the stem / progenitor population of the mammary epithelial cells, our result suggest that the upregulation of miR - 142 and its enhancement of the miR - 150 expression seem to be especially relevant in the breast tumor progression in vivo.