Sentences with phrase «epithelial tumor cells»

In a first set of experiments, postdoctoral researcher and co-lead author Max - Felix Häring found that insulin increased the proliferation of mouse epithelial tumor cells in culture, as expected.

Thus, epithelial tumor cells must undergo phenotypical changes that allow them to breach the basement membrane, invade adjacent tissues and ultimately form distant metastases.

Not exact matches

The now - mesenchymal cells can then travel to a remote site, where they eventually convert back to their epithelial state and clump together into a secondary tumor.

The mechanisms that promote or enable drug resistance include drug inactivation, drug target alteration, drug removal from cells, DNA damage repair, cell death inhibition and the epithelial - mesenchymal transition (EMT) that enable solid tumors to transform into more metastatic grades.

Part of the cytoskeleton, vimentin gives flexibility and structure to the cell, but it is also a marker of epithelial - mesenchymal transition (EMT), which is considered a crucial event for metastasis in epithelial tumors.

The study, which followed four individuals for a year after they were treated with embryonic stem cell - derived retinal pigment epithelial cells for macular degeneration, observed no serious side effects (tumor growth or other unexpected effects) related to the therapy.

«Our system is based around a molecule called E-cadherin, which suppresses tumor growth in part by maintaining cells in an epithelial rather than a mesenchymal state,» Tomoki Muramatsu of TMDU says.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

The cell changes, known as an epithelial to mesenchymal transition, or EMT, are normal and helpful during wound healing, but problematic when cancer cells spread from the primary tumor site to other sites in the body.

Different tumor subtypes can include glandular, which include the mammary glands, as well as squamous, which are very rare and involve epithelial cells that line the inside of the breast.

Unrestrained epithelial cell extrusion has been linked to tumor cell invasion and metastasis in other studies.

This study demonstrated that emulsifier - induced alterations in the microbiome were necessary and sufficient to drive alterations in intestinal epithelial cells» homeostasis, which is thought to govern tumor development.

The effects of consuming emulsifiers were eliminated in mice devoid of microbiota (germ - free mice), and transplanting microbiota from emulsifier - treated mice to germ - free mice was sufficient to transfer alterations in intestinal epithelial cells» homeostasis, suggesting a central role played by the microbiota in tumor development.

Collectively, these results suggest that Nrk negatively regulates the estrogen - dependent proliferation of mammary epithelial cells, the disruption of which leads to breast tumors.

The absence of tumors in virgin Nrk mutant mice strongly suggests that the tumorigenesis is closely related to the proliferation of mammary epithelial cells during pregnancy.

In Nrk mutant mammary glands, dense clusters of ER alpha - positive mammary epithelial cells were sometimes observed at late stages of pregnancy, which may represent the «bud» of the breast tumor.

Additionally, overexpression of POSTN in human mammary epithelial and breast cancer cells resulted in enhanced tumor growth and metastasis (Wang et al., 2013), which is similar to a colon cancer cell model where overexpression of POSTN resulted in an increase in the number and size of liver metastases (Bao et al., 2004).

Every tumor cell line the researchers tested that had the epithelial marker E-cadherin and not the mesenchymal marker Vimentin, had high amounts of miR - 200.

We use multiple mouse models combined with in vitro approaches to address the pleiotropic functions of these cytokines which affect both the epithelial cancer cells and the inflammatory infiltrate within tumors.

Moreover, following transformation with H - Ras, these cells initiated tumor xenografts in immunocompromised mice with higher efficiency than their epithelial counterparts [5].

The Joslin team found that intestinal tumors grow just as quickly in a mouse cancer model whose «epithelial» cells lining the inside of the intestine have been genetically modified so that insulin can't activate the cells.

Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism.

Oct4 Mediates Tumor Initiating Properties in Oral Squamous Cell Carcinomas through the Regulation of Epithelial - Mesenchymal Transition.

In the classical model of tumor dissemination, specialized cells at the invasive front undergo epithelial - mesenchymal transition (EMT) and enter peripheral tumor - coalescing blood vessels to establish metastatic lesions by extravasation of CTCs.

The epithelial - to - mesenchymal transition (EMT) and the reverse process (the mesenchymal - to - epithelial transition [MET]-RRB- have been shown to be associated with tumor cell invasion and metastasis in different carcinomas.

Keywords: Metastasis, Circulating Tumor Cells, Intravasation, Epithelial - Mesenchymal - Transition, Angiogenesis.

Oncologists have suspected for several decades that metastasis usually requires a transition between sticky epithelial cells, which make up the bulk of solid tumors, and thinner, more mobile mesenchymal cells that are often found circulating solo in cancer patients» bloodstreams.

These tumor promoting activities include inducing invasiveness and metastasis, epithelial - to - mesenchymal transition, stem cell - like features and drug resistance.

Moreover, ablation of a STAT5A allele reduces tumor incidence in a mouse model of breast cancer in which mammary epithelial cells express T antigen (48).

Cancer cells can also migrate collectively from epithelial tumors by wrapping around vessels or muscle fibers.

Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels

TGFβ inhibits tumor initiation and progression by inducing cell cycle arrest and apoptosis; however epithelial tumorigenesis may escape this common antitumor mechanism by inducing aberrations in TGFβ signaling resulting in enhanced development and progression of human carcinomas.

These cells were functionally heterogeneous, produced barrier - protective cytokines, and stimulated intestinal stromal and epithelial cells via interleukin 17A, interferon gamma, and tumor necrosis factor.

Interestingly, long - term — cultured human epithelial cancer cells in clonal cultures also form holoclones, meroclones, and paraclones, and tumor cell holoclones have been hypothesized to harbor stem - like cells or cancer stem cells.

We also found that several carriage strains had lost their type IV pili and that this loss correlated with reduced tumor necrosis factor alpha (TNF - α) expression when cultured with epithelial cells.

Carcinomas arise from epithelial cells, and tumor progression involves a loss of polarity, so an understanding of cell polarity is important in the identification of novel therapeutic approaches to cancer.

Last year, Mandriota and collaborators demonstrated that in a cancer mouse model, concentrations of aluminum in the amount of those measured in the human breast are able to transform cultured mammary epithelial cells, allowing them to form tumors and to metastasize.

More specifically, he researches the use of anti-CEA antibodies for tumor imaging and therapy, as well as the role of CEACAM1 in T - cell activation and mammary epithelial cell polarization.

Considering that miR - 142 is highly expressed in human BCSCs, but weakly expressed or undetectable in the stem / progenitor population of the mammary epithelial cells, our result suggest that the upregulation of miR - 142 and its enhancement of the miR - 150 expression seem to be especially relevant in the breast tumor progression in vivo.

Hepatocellular carcinoma is a malignant tumor of the epithelial cells of the liver.

TCC is a malignant tumor that develops from the transitional epithelial cells that line the bladder.

Stromal granulosa cell, epithelial tumors and dysgerminomas may become very large, in which case a swollen abdomen is the main sign.

Granulosa cell and epithelial tumors are the most common ovarian tumors in bitches.

Typically, the cells of benign and malignant mesenchymal tumors have poorly - defined cell membranes as compared to epithelial tumors.

These categories are epithelial tumors, mesenchymal tumors, round cell tumors and melanomas.

There are various types of bladder tumors like squamous cell carcinoma (arise in the epithelial cells), adenocarcinoma (arise in the glandular epithelium), undifferentiated carcinoma, rhabdomyosarcoma (tumor of the striated muscle - form of fibers combined into parallel fibers like the skeletal and the cardiac muscles), fibroma (tumors made of fibrous or connective tissue.

It is a tumor made up of the epithelial cells that line the bladder wall.