Not exact matches
M2e is only slightly present
on the virus, but in the lung
epithelium cells where the virus ends up and starts multiplying, in the invaded
cells, M2e becomes abundant.
«Previous studies primarily focused
on neurons and the retinal pigment
epithelium cells as culprits in degeneration,» said Eroglu, who is also a member of the Duke Institute for Brain Sciences (DIBS).
«Importantly, it demonstrates that one
cell type — the corneal
epithelium — could be further grown in the lab and then transplanted
on to a rabbit's eye where it was functional, achieving recovered vision.
The
epithelium's maturation into a villus intestinal
epithelium with long finger - like extensions was helped along by co-culturing human intestinal microvascular endothelial
cells on the opposite side of the shared matrix - coated porous membrane in the «vascular» channel where they assembled a surrogate blood vessel with a hollow lumen through which feeding medium was flowed.
Although this human Gut Chip recreated the villus
epithelium of normal intestine and enabled new insights into how flow and cyclic peristalsis affects intestinal differentiation and function, it could not be used to study processes that relied
on normal intestinal
cells from individual donors, which, for example, is crucial for studying patient - specific responses for personalized medicine.
The researchers analyzed the exposed
cells to determine the effects of fungal exposure
on permeability properties and barrier function of the
epithelium.
That process depends
on the presence of stem
cells tucked in the
epithelium underneath the nail, which is a luxury not available throughout the body.
Of the many types of polarized
epithelia, we have focused
on liver hepatocytes, which exhibit a complex polygonal polarity, and simple columnar
cells of the intestine.
Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, et
Cell therapy, as envisaged by the teams of I - Stem, is primarily based
on the identification of experimental protocols that can specifically guide differentiation of pluripotent
cells to a
cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, et
cell fate, which presents a interest for the replacement of the defective
cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, et
cell population from the patient (the striatal neurons for Huntington's disease, the
cells of the retinal pigment
epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).
The retinal neurons rely
on their supporting
cells, such as retinal pigment
epithelium (RPE)
cells, to provide them with the fuel to meet their energy needs.
We will mine and exploit information from studies and screens in model organisms, but our primary focus is
on the paradigmatic mammalian stem
cell systems - haematopoiesis and
epithelia in vivo, and embryonic and neural stem
cells in vitro.
The whole OM samples, including the main olfactory
epithelium and underlying lamina propria, non-neuronal supporting
cells, glandular tissue and blood vessels with blood [23], yielded 46.4 million (± 4.3 million) fragments
on average (Table 1).
Wing primordia subjected to CIN are characterised by tumor - like overgrowths, metastatic behavior and malignancy to the host upon blockade of the apoptotic machinery, and this tumorigenic response relies mainly
on the production of highly aneuploid
cells that delaminate from the
epithelium and activate a JNK - dependent transcriptional response.
To further examine the morphology of
cells and the localization of protein expression within the retina, immunohistochemical staining of both paraffin and OCT retinal sections was performed with the following antibodies (Table S1): human cone arrestin (for cone photoreceptors), rhodopsin (for rod photoreceptors), RPE65 (for the retinal pigment
epithelium, RPE), glial fibrillary acidic protein (GFAP, for astrocytes and Müller
cells), glutamine synthetase (for Müller
cells) and G0alpha (for
ON bipolar
cells).