Sentences with phrase «epithelium for»

Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).

Searching for an explanation to this alternate pheromone - detection system, neuroscientists Stephen Liberles and Linda Buck of the Fred Hutchinson Cancer Research Center in Seattle scanned the mouse olfactory epithelium for potential pheromone receptors.

Researchers used transgenic mice that expressed MMP9 in the colonic epithelium for in vivo experiments.

Not exact matches

For instance, people with interstitial cystitis may also have a defect in the protective lining (epithelium) of the bladder.

A layer of cells called the retinal pigment epithelium (RPE) is essential for supporting and nourishing the retina cells that capture light for vision.

«The study analysed the genome of these eight species and performed comparative analysis of animal genes important for signalling, neuronal and ionic conduction, epithelia, immunity and reproduction, which are the basic functions associated to multicellularity,» she adds.

«These data show for the first time that obesity is associated with increased DNA damage in breast epithelium of BRCA mutation carriers,» lead study author Priya Bhardwaj, a Ph.D. student at Weill Cornell Medicine in New York, N.Y., and colleagues write in their abstract.

In an initial group of patients experiencing asthma attack, nasal epithelia cells were collected and tested for comparative VNN - 1 expression.

The pharmacologists and toxicologists Prof. Dr. Dr. Klaus Aktories and Dr. Panagiotis Papatheodorou from the University of Freiburg have identified the molecular docking site that is responsible for the C. difficile toxin's being able to bind to its receptor on the membrane of the intestinal epithelium.

This indicated that a disrupted cross-signaling between mesenchyme and epithelium was the reason for the failed maturation of ameloblasts.

Since it is known that 13 different members of the fibroblast growth factor, or Fgf, family act as signaling proteins between the two different tissues — dental mesenchyme and oral epithelium — during murine tooth development, Javed and colleagues looked for changes in Fgf ligands in the mice lacking Sp7.

«Previous studies primarily focused on neurons and the retinal pigment epithelium cells as culprits in degeneration,» said Eroglu, who is also a member of the Duke Institute for Brain Sciences (DIBS).

However, two types of cells in the olfactory epithelium (specialized tissue responsible for sense of smell), are mixed together and form a mosaic pattern despite expressing different types of cadherins.

It first targets a protective lining called the retinal pigment epithelium (RPE), which shuttles nutrients to the photoreceptor cells and is vital for their survival.

This form of interference with bacterial gene regulation is also of pharmaceutical interest as it is known that pathogenic bacteria can protect themselves against attack by the immune system and the effect of antibiotics by forming biofilms, for instance on the epithelium of the respiratory system.

While the simple proteins called histatins are well known for their ability to ward off infections, biochemist Menno Oudhoff of the University of Amsterdam discovered a subset of histatins that also prompt cells from the skin's surface, called the epithelium, to close over a wound.

Scientists from the Spanish National Cancer Research Centre (CNIO) have discovered that NANOG, an essential gene for embryonic stem cells, also regulates cell division in stratified epithelia — those that form part of the epidermis of the skin or cover the esophagus or the vagina — in adult organisms.

For example, there have been cases of transplanting retinal pigment epithelium and spine cells from stem cells.

Although this human Gut Chip recreated the villus epithelium of normal intestine and enabled new insights into how flow and cyclic peristalsis affects intestinal differentiation and function, it could not be used to study processes that relied on normal intestinal cells from individual donors, which, for example, is crucial for studying patient - specific responses for personalized medicine.

«Once the mechanism is understood, it can be exploited in different ways to promote health,» says Andrew Gewirtz, who studies the intestinal epithelium at Georgia State University's Center for Inflammation Immunity & Infection and is senior author of one of the papers.

About 10 % of cases are due to a mutation in retinal pigment epithelium 65 (RPE65), a gene that codes for an enzyme that helps retinal cells make rhodopsin.

In immunocompromised individuals (chemotherapy patients, for example) or poorly controlled diabetics, upper airway Aspergillus infections can invade the mucosa and underlying tissue and become lethal, so it is particularly critical to understand its interactions with the airway epithelium.

During embryonic development, mesenchyme (embryonic stroma) is critical for pancreatic development even though only the epithelium gives rise to the pancreas.

This would contrast sharply with the rather abundant supply of stem cells for the corneal epithelium that are known to occur in the anterior limbus [11].

Lipidoid Nanoparticles for siRNA Delivery to the Intestinal Epithelium: In Vitro Investigations in a Caco - 2 Model.

The new iPS cells passed the standard tests for pluripotency: They formed tumors called teratomas when injected into immunocompromised mice, and they could differentiate into cells from the three main tissue types in the body, including neurons, muscle and gut epithelium.

However, inflammation and metabolic stress caused by components of the tumor epithelium can result in non-genetic vulnerabilities that can be potentially exploited for the design of innovative therapeutic approaches.

Three - dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium.

Role of IL - 17A, IL - 17F, and the IL - 17 receptor in regulating growth - related oncogene - α and granulocyte colony - stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis.

Similarity between the osteoblasts and the calicoblastic epithelium cells of scleractinian coral was also shown in the localization of the protein BMP in the tissue of S. pistillata (Zoccola et al., 2009), and for its role in the coral biomineralization (Mass et al., 2016; Zoccola et al., 2009).

imaginal epithelia, clones of oncogenic cells mutant for apico - basal polarity genes are actively eliminated when surrounded by wild - type cells.

Abstract Purpose: To test the effect of tetrahydropyridoethers (THPE) on pigment granules of the retinal pigment epithelium (RPE), monkeys (Macaca fascicularis) were orally treated with this drug for up to one year.

Tetrahydropyridoethers Eliminate Lipofuscin From Retinal Pigment Epithelium of Monkeys U. Schraermeyer , S. Schultheiss , S. Hofmeister and S. Julien Experimental Vitreoretinal Surgery, Institute for Ophthalmic Research, Tubingen, Germany Commercial Relationships: U. Schraermeyer, None; S. Schultheiss, None; S. Hofmeister, None; S. Julien, None.

Here we present a novel human Airway Lung - Chip containing a fully - differentiated human mucociliary airway epithelium separated from a pulmonary microvascular endothelium by a semi-permeable membrane that allows for immune cell infiltration.

Translocation of B. anthracis across mucosal epithelia is key for its dissemination and pathogenesis.

These findings establish Frizzled family receptors as disease - relevant receptors for toxin B in the colonic epithelium and provide novel therapeutic targets for treating C. difficile infections.

Diseases of the retina may offer an early test bed for hiPSC - derived cells, in the form of retinal pigmented epithelium, given the relative isolation of the tissue, and the small number of cells required [14].

In this model, OspA is proposed to be an adhesin that tethers the spirochetes to the midgut epithelium (5, 6), whereas OspC is thought to be important for movement of the spirochete within the tick (7, 8).

Accelerated Three - Dimensional Neuroepithelium Formation from Human Embryonic Stem Cells and Its Use for Quantitative Differentiation to Human Retinal Pigment Epithelium.

Important features of XMRV biology include (1) tropism for a variety of cell lines, including prostate cancer DU145 and LNCaP cells [27], [43], [48], and human neural cell types [57], (2) adaptations that promote growth in prostate epithelium and human - derived prostate cancer cell lines including an androgen response element in the promoter region [58] and downregulation of APOBEC3G [59], and (3) cellular effects with potential oncogenic properties including increased tumor aggressiveness mediated by downregulation of p27 [60] and differential regulation of several microRNAs [61].

The retinal pigment epithelium (RPE) is a monolayer of cells, residing at the back of the eye between Bruch's membrane and the retina, which is essential for photoreceptor function and survival.

My research demonstrated that Dnmt1 is required for mouse intestinal development, but is not required for survival of the mature adult intestinal epithelium.

In these cases, UroSEEK could be detecting clonal proliferations in the bladder epithelium that did not progress to cancer, and such proliferations may be more common in patients with BC than in the general population Risques and Kennedy, 2018Because only one biopsy from the primary tumor was available for comparison, it is also possible that intratumoral heterogeneity explains some of the discrepancies.

Using conditional genetic ablation of Ar in Sertoli cells, we have shown that AR signaling is required for three stages of spermatogenesis: progression through meiosis I, the differentiation of haploid round spermatids into elongating spermatids, and spermiogenesis, the release of fully differentiated elongated spermatids into the lumen of the seminiferous epithelium.

We found these DEGs significantly enriched for the following Gene Ontology (GO) biological processes: «epithelial cell differentiation» and «epithelium development» (FDR ≤ 0.05; Dataset S20).

Unfortunately, not everyone who develops Celiac disease will have recognizable symptoms before the condition has wreaked serious havoc in the intestinal system by flattening of the villus epithelium and subsequently decreasing the area for nutrient absorption.

A protein called zonulin is responsible for induction of tolerance and orchestration of immune responses by modulating intercellular tight junctions in the gastrointestinal epithelium in a rapid, reversible, and reproducible fashion (Fasano, 2011).

The epithelium of the small bowel is essential for the absorption of all major nutrients.

Glutamine is critical to intestinal health because it serves as the primary metabolic fuel for the rapidly dividing cells of intestinal epithelium.

These SCFA are the prime substrates for the energy metabolism in the colonocyte and they act as growth factors to the healthy epithelium.