Sentences with phrase «epitopes from»

Acute infection of C57BL / 6 mice with murine CMV elicits a very broad CD8 T cell response, comprising at least 24 epitopes from 18 viral proteins.

The identification of potentially pathogenic and therapeutic epitopes from common human allergens.

He is working on the prediction and validation of conserved T cell epitopes from prevalent swine influenza viruses.

It breaks down gluten in the stomach to eradicate the proline - rich T - cell stimulatory epitopes from gluten proteins before they reach the small intestine.

POL6326 is designed through protein epitope mimetic (PEM) approach, where epitope from a recombinant protein is transferred to a synthetic scaffold [120].

Not exact matches

A viral epitope inserted into the complementarity - determining region 3 (CDR3) loop of the heavy chain of a self immunoglobulin (Ig) molecule was generated from the Ig context and was presented by I - Ed class II molecules to virus - specific, CD4 + T cells.

Complexes with HAs from the group 1 H1 and the group 2 H3 subtypes analyzed by x-ray crystallography showed that the antibody bound to a conserved epitope in the F subdomain.

In laboratory experiments, Gefter and his colleagues showed that T cells from allergic people can be made tolerant to the complete allergen if they are presented beforehand with isolated epitopes.

Funded by grants from the National Institutes of Health, scientists at Blood Systems Research Institute (BSRI) in San Francisco and the Washington University School of Medicine in St. Louis have found that neutralizing antibodies that engage epitopes including residue E2 - W64 are highly potent at inhibiting the virus in mice, due to the importance of E2 - W64 in pathogenicity.

Some examples from their lab include using AAV to introduce epitope tags into the endogenous alleles of the p53 and PTEN tumor suppressor genes in human cells (Kim et al 2008).

Based on these observations, we postulate that the plasmablasts producing these broadly neutralizing antibodies were predominantly derived from activated memory B cells specific for epitopes conserved in several influenza strains.

This antibody binds to the D664KW666 core 2F5 epitope but use entirely different germ line V genes from 2F5 and that are significantly less divergent than 2F5 from thei

mAb 246 - D binds to overlapping hexapeptides which identified its core epitope as qqLLGIwg (aa 591 - 598) which is located in the immunodominant region (cluster I) of gp41, just upstream from

Insert for human APOBEC3G was cloned into mammalian expression vector pcDNA3 with a V5 epitope tag from SV5 paramyxovirus and a polyhistidine epitope at the C terminus.

The Sette lab's research on DENV encompasses large - scale epitope identification (supported by an HHS contract) and diverse studies towards understanding the role of T cells and HLA variants in the development of (or protection from) DENV disease (supported in part by a consortium grant led by Eva Harris at UC Berkeley).

The IEDB catalogs all epitopes for humans, non-human primates, rodents, and other vertebrates, from allergens, infectious diseases, autoantigens and transplants, and includes epitope prediction tools to accelerate immunology research around the world.

From those studies he and his collaborators further developed the notion that different MHCs have distinct binding specificities that can be used to predict epitopes.

and affinity of antibody ACI - 5400 were characterized by a panel of methods: (i) measuring the selectivity for a specific phospho - Tau epitope known to be associated with tauopathy, (ii) performing a combination of peptide and protein binding assays, (iii) staining of brain sections from mouse preclinical tauopathy models and from human subjects representing six different tauopathies, and (iv) evaluating the selective binding to pathological epitopes on extracts from tauopathy brains in non-denaturing sandwich assays.

The study, «Dengue Virus Envelope Dimer Epitope Monoclonal Antibodies Isolated from Dengue Patients Are Protective against Zika Virus,» was published in the July / August issue of mBio, the journal of the American Society for Microbiology.

I have been at La Jolla Institute for Allergy and Immunology since 2006 as a Senior Curator, responsible for compiling immunology data from the scientific literature with specific emphasis on extracting information about B and T cell epitopes into an NIAID - funded database, the Immune Epitope Database (IEDB).

Using sera from malaria - immune adults, it has been shown that the expressed recombinant proteins contained heat - labile epitopes suggesting that they adopt their native conformation and are likely to be biochemically active.

By using sera from malaria - exposed immune adults, the immunoreactivity of 20 recombinant proteins was assessed, and most of the merozoite ligands were found to carry heat - labile epitopes.

In addition to the scientists named above, the contributors to the first paper, «Broadly neutralizing HIV antibodies define a novel glycan - dependent epitope on the pre-fusion conformation of gp41 on cleaved Envelope trimers,» were Alejandra Ramos, Jeong Hyun Lee, Chi - Hui Liang and Pascal Poignard, all from TSRI and IAVI Neutralizing Antibody Center; Alejandro Ramirez, Ryan McBride, Michael B. Zwick and James C. Paulson from TSRI; Katie J. Doores from King's College London School of Medicine; Ronald Derking, Marit J. van Gils and Rogier W. Sanders from the Academic Medical Center, Amsterdam; Sachin S. Shivatare, Chung - Yi Wu and Chi - Huey Wong of Academia Sinica, Taipei, Taiwan; Po - Ying Chan - Hui and Kristine Swiderek of Theraclone Sciences, Inc., Seattle; Yan Liu and Ten Feizi of Imperial College London; Michael S. Seaman of Beth Israel Deaconess Medical Center in Boston; John P. Moore of Weill Medical College of Cornell University; and Wayne C. Koff of IAVI in New York City.

In the latest publication from Future Science OA, John Enrique Mata and colleagues from Oregon State University (OR, USA) and Western University of Health Sciences (CA, USA) assess a novel membrane - spanning peptide (MSP) expressing the isoleucine - lysine - valine - alanine - valine (IKVAV) epitope in mice, following hemilaminectomy and compression injury.