Sentences with word «epoxide»

Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with forearm vasodilator responses in humans.

The problem was an enzyme called soluble epoxide hydrolase (sEH), which breaks down and inactivates EDP.

To make this discovery, Serhan and colleagues deconstructed the biosynthetic pathway for maresin biosynthesis and found that human macrophages are responsible for converting DHA to the novel epoxide intermediate «13S, 14S - epoxy - maresin.»

• Developed more than ten chiral HPLC methods for enantiomeric separation of epoxides, diols, seleno - alcohols, ester and carbamates.

Why this dramatic difference between α - tocopherol and tocotrienols in preventing the oxidative formation of E2 epoxide?

It works by interfering with vitamin K epoxide reductase, an enzyme involved in the blood clotting process.

Because warfarin works by interfering with the enzyme vitamin K epoxide reductase, variations in the gene coding for this enzyme (VKORC1) can affect an individual's sensitivity to warfarin.

E2 can be activated by epoxide - forming oxidants resulting in the ability to bind to DNA and form DNA adducts, which can cause mutation leading to carcinogenesis.

The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4.

The role of polyunsaturated fatty acid - derived epoxides and diols in angiogenesis and lymphangiogenesis Giorgia Ciliberti, Goethe University Frankfurt

Characterization of a tobacco epoxide hydrolase gene induced during the resistance response to TMV

The researchers have shown the enzyme called soluble epoxide hydrolase (sEH) to be capable of reducing the symptoms of diabetes in mice by stabilizing metabolites in an omega - 3 acid called DHA.

Decreasing soluble epoxide hydrolase has become a target by drug companies, in order to produce medication in order to reduce hypertension, inflammation and tobacco - induced lung inflammation.

In that initial screen, the most efficient particle contained the amino acid lysine linked to an epoxide, so the researchers created an additional 43 nanoparticles similar to that one, for further testing.

There are 21 amino acids found in multicellular organisms; the researchers created about 60 lipopeptide particles, each containing a different amino acid linked with one of three chemical groups — an acrylate, an aldehyde, or an epoxide.

In the new study, postdoc Stephan C. Hammer, now at the University of Stuttgart, found that the enzyme actually made 45 % aldehyde directly, without going through an epoxide intermediate.

The Caltech researchers started with an iron - based cytochrome P450 enzyme called P450LA1because it catalyzes a related reaction, metal - oxo alkene oxidation, in which a metal - linked oxygen attacks the double bond, typically forming an epoxide.

An earlier study by another group had found that P450LA1 also made 19 % aldehyde side - product by opening the epoxide.

Research evaluating and comparing the ability of α - tocopherol, α - tocotrienol, γ - tocotrienol and δ - tocotrienol in preventing the formation of E2 epoxide and the initiation of E2 epoxide - induced breast cancer found all three tocotrienols were more potent antioxidants and more effective than α - tocopherol.29

However, Coffeeberry ® is not done yet... Coffeeberry ® and sEH Soluble epoxide hydrolase, or sEH, is another enzyme produced by your body, and lends a hand in many different reactions.

Ellagic acid treatment of preweanling mice before an injection of B (a) P diol - epoxide caused a 44 - 75 % inhibition in the number of diol - epoxide - induced lung tumors (Chang).